HIF-1α、VEGF在外阴鳞状细胞癌中的表达与临床意义

目的:探讨缺氧诱导因子-1α(hypoxia inducible factor-1 alpha,HIF-1α)与血管内皮生长因子(vascular endothelial growth factor,VEGF)在外阴鳞状细胞癌(vulvar squamous cell carcinoma,VSCC)中的表达及其相互关系。方法:用免疫组化SP法检查43例VSCC中HIF-1α、VEGF蛋白表达。结果:VSCC中HIF-1α与VEGF阳性表达率分别为72.09%(31/43),76.74%(33/43),均明显高于外阴正常表皮(P<0.01)。随着病理分级、临床分期的增加及淋巴结转移的发生,HIF-1α与VEGF阳性表达率也随之增加,差异有显著性(P<0.05)。HIF-1α与VEGF表达呈正相关(rs=0.866,P<0.01)。结论:HIF-1α、VEGF是反映VSCC浸润转移等生物学行为的重要指标,HIF-1α诱导VEGF表达从而促进肿瘤血管生成可能参与VSCC的进展。

Expressions and the clinical significance of HIF-1 alpha and VEGF in the vulgar squamous cell carcinoma

Objective:To explore the expression of hypoxia inducible factor-1 alpha(HIF-1α) and vascular endothelial growth factor(VEGF) in vulvar squamous cell carcinomas(VSCC)and their relationship.Methods:The expression of the HIF-1αproduct was detected by immunochemistry in the tissue samples of 10 cases of normal vulvas and 43 cases of VSCC.Results:The positive rates of HIF-1α and VEGF protein in the VSCC were 72.09%(31/43)and 76.74%(33/43) respectively,with significant difference from the control group(P<0.01).With the increase of pathological grades,clinical stages and the occurrence of lymphode metastasis,the positive expression rates of HIF-1α and VEGF protein in the VSCC raised(P<0.05).There was a positive correlation between HIF-1α and VEGF(rs=0.866,P<0.01).Conclusion:HIF-1α may play an important role in angiogenesis and tumor progression by regulating the expression of VEGF in VSCC.