脑梗塞患者周围血细胞因子研究

本文对２６名健康对照者及３４例脑梗塞患者急性期和恢复期外周血单个核细胞（ＰＢＭＣ）白细胞介素－１（ＩＬ－１）、白细胞介素－６（ＩＬ－６）活性及血清肿瘤坏死因子（ＴＮＦ）水平进行检测。结果示：急性期和恢复期脑梗塞患者ＰＢＭＣＩＬ－１、ＩＬ－６活性及血清ＴＮＦ水平较对照者明显增高，急性期脑梗塞患者又较恢复期脑梗塞患者高，均有显著性差异（Ｐ＜０．０１）；增高的程度与梗塞灶大小密切相关。提示：脑梗塞后早期炎症反应、细胞因子的产生在脑缺血和（或）再灌注损伤中可能起着重要作用。

The study of cytokines in peripheral blood of patients with cerebral infarction

The activity of interleukin-1(IL-1),Interleukin-6(IL-6)of peripheral blood mononuclear cells(PBMC)as well as the level of tumor necrosis factor(TNF)in serum were measured in 26 normal controls and 34 patients with acute and recovery cerebral infarction.Results showed that:the activity of IL-1,IL-6 of PBMC as well as the level of TNF in serum of the patients with acute and recovery cerebral infaction were significantly higher than those of normal controls(P<0.01);the high activity of IL-1,IL-6 of PBMC as well as the high level of TNF in serum were related to volume of infarct.The results indicated that early inflammatory response,producing of cytokines may play a key role in cerebral ischemic reperfusion injury after cerebral infarction.