| 参附汤对休克大鼠不同器官糖皮质激素受体的上调作用 |
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| 引用本文： | 凌昌全,李敏,谭金兴,潘瑞萍,黄雪强.参附汤对休克大鼠不同器官糖皮质激素受体的上调作用[J].浙江中医药大学学报,2003,27(3):56-57. |
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| 作者姓名： | 凌昌全 李敏 谭金兴 潘瑞萍 黄雪强 |
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| 作者单位： | 1. 第二军医大学附属长海医院,上海,200433
2. 第二军医大学 |
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| 基金项目： | 国家杰出青年基金:No:30025045 |
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| 摘 要： | 目的：探讨参附汤临床益气回阳救逆功效的作用机制。方法：以失血性休克大鼠为模型，观察参附汤对失血性大鼠血浆皮质酮(GC)、促肾上腺皮质激素(ACTH)及脑、肝、胸腺等部位糖皮质激素受体(GCR)的影响。结果：参附汤对失血性休克大鼠脑、肝、胸腺等部位的糖皮质激素受体活性有明显的上调作用。结论：参附汤通过保护GCR，提高机体GC系统在失血性休克过程中的生物学效应，可能是其临床益气回阳救逆功效的重要作用机制之一；参附汤上调失血性休克大鼠糖皮质激素受体的作用未见器官特务性。
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| 关 键 词： | 失血性休克 大鼠 糖皮质激素受体 参附汤 益气回阳救逆功效 |
| 修稿时间： | 2002年5月14日 |
Up-Regulation of Glucocorticoid Receptor by Shenfu Decoction in Different Organs of Shock Rats |
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| Ling Changquan,Li Min,Tan Jinxing,et al Changhai Hospital Affiliated to Second Military University,Shanghai.Up-Regulation of Glucocorticoid Receptor by Shenfu Decoction in Different Organs of Shock Rats[J].Journal of Zhejiang University of Traditional Chinese Medicine,2003,27(3):56-57. |
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| Authors: | Ling Changquan Li Min Tan Jinxing Changhai Hospital Affiliated to Second Military University Shanghai |
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| Abstract: | Objective:To investigate the mechanism of pharmacological action of Shenfu Decoction in invigorating qi and reviving yang for resuscitation.Methods:The effects of Shenfu Decoction on glucocorticoid(GC)and adrenocorticotropic hormone(ACTH)in plasma and glucocorticoid receptor (GCR)in brain,liver and thymus of hemorrhagic shock rats were measured.Results:Shenfu Decoction up regulated the activity of GCR in brain,liver and thymus of hemorrhagic shock rats obviously.Conclusion:Shenfu Decoction increased the biological effect of GC during the procedure of hemorrhagic shock by protecting the GCR.This is a potential mechanism of Shenfu Decoction in invigorating qi and reviving yang for resuscitation.The up regulation of glucocorticoid receptor by Shenfu Decoction in hemorrhagic shock rats exhibits no organ specificity. |
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| Keywords: | Shenfu Decoction receptor glucucorticoid hemorrhagic shock rats |
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