辣木叶黄酮对缓解小鼠运动性疲劳的影响

研究辣木叶黄酮对过度训练小鼠抗疲劳的功效。将小鼠随机分为5组(共50只,每组10只),分别为辣木叶黄酮低剂量组100 mg/(kg·d)]、中剂量组200 mg/(kg·d)]、高剂量组400 mg/(kg·d)]、模型组蒸馏水100 mg/(kg·d)]和对照组红景天西洋参胶囊200 mg/(kg·d)],连续灌胃8周,同时通过跑台训练建立小鼠过度训练模型,辣木叶黄酮各剂量组与模型组和对照组进行比较,评价过度训练小鼠抗疲劳能力相关指标。结果显示:与模型组比较,辣木叶黄酮各剂量组小鼠运动后体内肝糖原和肌糖原储备量、血清和肝组织中过氧化氢酶活力、超氧化物歧化酶活力及谷胱甘肽过氧化物酶活力显著升高(P<0.05),血清中乳酸含量、尿素氮含量、乳酸脱氢酶活力、肌酸激酶活力和丙二醛含量显著降低(P<0.05);与对照组比较,辣木叶黄酮中、高剂量组没有显著差异。表明辣木叶黄酮具有缓解运动性疲劳的作用。

Effects of Flavonoids from Moringa oleifera Leaves on Relieving Sports Fatigue in Mice

The anti fatigue effects of flavonoids from Moringa oleifera leaves on overtraining in mice was studied.The mice were randomly divided into five experimental groups(50 mice,10 in each group),which were fla-vonoids from Moringa oleifera leaves low-dose group 100 mg/(kg·d)],medium-dose group 200 mg/(kg·d)],high-dose group 400 mg/(kg·d)],model group distilled water 100 mg/(kg·d)] and control group rhodiola and American ginseng capsule 200 mg/(kg·d)]. The mice were gavaged and overtraining for 8 weeks,then the low-dose,medium-dose and high-dose groups were compared with the model group and control group to evaluate the levels of anti-fatigue. The results indicated that,compared with the model group,the reserve of hepatic glycogen and muscle glycogen in the low-dose,medium-dose and high-dose groups significantly increased and the activity of catalase,superoxide dismutase and glutathione peroxidase significantly increased in serum and liver tissue(P<0.05). In addition,the levels of lactic acid,urea nitrogen and malondialdehyde significantly decreased and the activity of lactate dehydrogenase and creatine kinase significantly decreased in serum(P<0.05). Furthermore,compared with the control group,all differences were not significant in the medium-dose and high-dose group. Flavonoids from Moringa oleifera leaves can relieve sports fatigue.