肝细胞癌组织中PCNA和nm23的表达与转移的关系

目的：探讨PCNA和nm23的表达与肝细胞癌（HCC）转移的关系。方法：采用免疫组织化学技术检测56例HCC中PCNA和nm23蛋白的表达。结果：56例HCC中，PCNA和nm23的表达强度均与HCC分化程度呈明显相关，分化愈差，PCNA表达愈强，而nm23表达愈弱；PCNA和nm23的表达强度呈明显负相关（P＜0.01)；有转移组PCNA的表达强度明显高于无转移组（P＜0.01) ,而nm23则相反（P＜0.01)。结论：PCNA和nm23蛋白的表达水平能反映HCC的分化程度和发生转移的潜能，可作为判断HCC预后的参考指标之一。

Expression of proliferating cell nucleus antigen and nm23 protein and their relation with metastasis in hepatocellular carcinoma]

OBJECTIVE: To investigate the expression of proliferating cell nucleus antigen (PCNA) and nm23 protein in hepatocellular carcinoma (HCC) and their relation with metastasis. METHODS: The expression of PCNA and nm23 protein in 56 HCCs were detected by the immunohistochemical technique. RESULTS: Of the 56 HCCs, the expression strength of PCNA and nm23 protein were significantly related to the differentiation degree of HCC: the poorer the differentiation of HCC, the stronger the PCNA expression, and the weaker the nm23 protein expression. The correlation analysis indicated that the strength of the PCNA expression was negatively related to that of nm23 (P < 0.01). The intensity of PCNA expression in HCCs with metastasis was significantly higher than that in HCCs without metastasis (P < 0.01), which was inverse with nm23 protein (P < 0.01). CONCLUSION: The level of PCNA and nm23 protein may reflect the differentiation degree and metastasis potential of HCC, and may be one of the useful parameters for judging prognosis of HCC.