| 5,7-二氯-2-辛基-1H-吲哚的合成研究 |
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| 引用本文： | 陶李明,刘文奇,周芸,李明.5,7-二氯-2-辛基-1H-吲哚的合成研究[J].化学世界,2011,52(2):97-99. |
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| 作者姓名： | 陶李明 刘文奇 周芸 李明 |
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| 作者单位： | 湘南学院化学与生命科学系,湖南郴州,423000 |
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| 基金项目： | 湖南省自然科学基金资助项目 |
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| 摘 要： | 以2,4-二氯-6-碘苯胺为原料,通过Sonogashira交叉偶联反应以及环合反应合成5,7-二氯-2-辛基-1H-吲哚,反应总收率为86.8%,该反应条件温和,收率较高,产物立体选择性好,产物结构经1H NMR和MS得到了确证.
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| 关 键 词： | 2 4-二氯-6-碘苯胺 合成 5 7-二氯-2-辛基-1H-吲哚 |
Study on the Synthesis of 5,7-Dichloro-2-octyl-1H-indole |
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| TAO Li-ming,LIU Wen-qi,ZHOU Yun,LI Ming.Study on the Synthesis of 5,7-Dichloro-2-octyl-1H-indole[J].Chemical World,2011,52(2):97-99. |
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| Authors: | TAO Li-ming LIU Wen-qi ZHOU Yun LI Ming |
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| Affiliation: | TAO Li-ming,LIU Wen-qi,ZHOU Yun,LI Ming(Department of Chemistry and Life Science,Xiangnan University,Hunan Chenzhou 423000,China) |
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| Abstract: | 5,7-Dichloro-2-octyl-1H-indole was synthesized through Sonogashira coupling reaction and annulation reaction using 2,4-dichloro-6-iodoaniline as the initial material.The reaction was readily performed with good yield and good selectivity under mild conditions and convenient operations.The yield of 5,7-dichloro-2-octyl-1H-indole was up to 86.8%.The product was determined by MS and()~1H NMR spectroscopy. |
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| Keywords: | 2 4-dichloro-6-iodoaniline synthesis 5 7-dichloro-2-octyl-1H-indole |
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