术后确诊的小细胞肺癌联合放化疗疗效分析

目的回顾性总结及评价手术后确诊的小细胞肺癌（SCLC）患者44例联合放化疗治疗的疗效。方法44例SCLC患者中,Ⅰ期15例（34.1%）,Ⅱ期13例（29.6%）,Ⅲ期12例（27.3%）,Ⅳ期4例（9.1%）,除肺段切除1例外均行肺叶或全肺切除,术后均用＂依托泊苷＋顺铂或卡铂＂或＂紫杉醇＋顺铂或卡铂＂方案化疗4～8个疗程,分别随访1,3,5年生存率。结果44例小细胞肺癌（SCLC）患者的1,3,5年总的生存率分别为84.3%、48.2%和18.1%。Ⅰ期、Ⅱ期患者采用术后联合放、化疗,可以获得较好疗效,Ⅲ期、Ⅳ期患者首选手术对生存率无益。结论手术后联合放、化疗对Ⅰ～II期的SCLC具有良好的治疗效果。

Efficacy of radiotherapy and chemotherapy in treatment of small cell lung cancer confirmed after operation-Analysis of treatment in 44 patients

Objective To analyze and evaluate retrospectively the efficacy of chemotherapy and radiotherapy in 44 patients with small cell lung cancer（SCLC） confirmed after operation.Methods Fortyfour patients with SCLC：stage Ⅰ,15 cases（34.1%）,stage Ⅱ,13 cases（29.6%）,stage Ⅲ,12 cases（27.3%） and stageⅣ,4 cases（9.1%） were analyzed.All of them had undergone radical operation except 1 segmentectomy case,and all received chemotherapy for 4-8 cycles with＂etoposide ＋ cisplatin or carboplatin＂or＂taxinol ＋ cisplatin or carboplatin＂regimen after operation.The patients were followed up for 1,3,5year survival rates.Results The 1,3,5-year survival rates of 44 cases were 84.3%,48.2% and 18.1% respectively.The efficacy of the postoperative treatment with combined chemotherapy and radiotherapy for stageⅠandⅡcases was good,but was not useful for stage Ⅲ and Ⅳ cases.Conclusion Postoperative treatment with combined chemotherapy and radiotherapy had good therapeutic effects for stagesⅠandⅡ SCLC.