Continuous,homogeneous and rapid synthesis of 4-bromo-3-methylanisole in a modular microreaction system |
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Authors: | Pei Xie Kai Wang Jian Deng Guangsheng Luo |
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Affiliation: | The State Key Laboratory of Chemical Engineering, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China |
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Abstract: | 4-Bromo-3-methylanisole is mainly used to synthesize black fluorane dye(2-anilino-3-methyl-6-dibutylaminofluorane, ODB-2), which is one of the most important heat and pressure-sensitive dyes in the manufacture of thermal papers. Compared to the industrial heterogeneous batch process, a continuous homogeneous bromination technology in a modular microreaction system has been developed, and 4-bromo-3-methylanisole has been successfully prepared through high-selective mono-bromination of 3-methylanisole with Br_2 solution in CHCl_3. In optimal conditions, the content of bis-brominated byproducts can be controlled less than 0.5%,which is superior to the industrial standard with 99.5% 3-methylanisole conversion at very short residence time and mild reaction temperature. |
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Keywords: | 4-bromo-3-methylanisole bromination continuous synthesis modular microreaction system mixing enhancement |
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