| 急性白血病患者MGMT基因突变的研究 |
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| 引用本文： | 齐华 李晓变. 急性白血病患者MGMT基因突变的研究[J]. 新乡医学院学报, 1999, 16(2): 124-126 |
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| 作者姓名： | 齐华 李晓变 |
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| 作者单位： | 河南医科大学医学遗传研究所 |
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| 摘 要： | 目的研究甲基鸟嘌呤－脱氧核糖核酸－甲基转移酶（ＭＧＭＴ）基因突变与急性白血病发病的关系。方法应用聚合酶链反应－单链构象多态性（ＰＣＲ－ＳＳＣＰ）技术对６２例急性白血病中ＭＧＭＴ基因进行了突变分析。结果ＭＧＭＴ基因突变在急性白血病中为１４．５％。结论急性白血病中存在ＭＧＭＴ基因突变，其在急性白血病的发生与发展中起到一定作用。
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| 关 键 词： | 甲基鸟嘌呤－脱氧核糖核酸－甲基转移酶基因；急性白血病；聚合酶链反应－单链构象多态性；基因突变 |
Study of MGMT gene mutations in cases of acute leukemia |
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| QI Hua,LI Xiao-Wen,YOU Wen-Feng,et al. Study of MGMT gene mutations in cases of acute leukemia[J]. Journal of Xinxiang Medical College, 1999, 16(2): 124-126 |
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| Authors: | QI Hua LI Xiao-Wen YOU Wen-Feng et al |
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| Abstract: | Objective To research the correlation between O6-methyl guanine-DNA-methyl transferase(MGMT) gene mutations and acute leukemia. Method Sixty two patients with acute leukemia were detected for mutations in MGMT gene using polymerase chain reaction-single strand conformation polymorphism(PCR-SSCP). Results 14.5% patients with acute leukemia contained MGMT gene mutations . Conclusion There are MGMT gene mutations in acute leukemia and MGMT gene mutations may play an important role in the pathogenesis of acute leukemia. |
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| Keywords: | O6-methylguanine-DNA mythytransferase gene acute leukemia polymerase chain reaction-single strand conformation polymorphism gene mutation |
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