动脉化疗栓塞术联合微波消融及静脉化疗治疗消化道肿瘤肝转移临床观察

目的：探讨动脉化疗栓塞术（transcatheter arterial chemoembolization ，TACE）联合微波消融及静脉化疗治疗消化道肿瘤肝转移的临床价值。方法不能或不愿手术的消化道肿瘤肝转移患者72例，随机分为2组。联合治疗组37例，序贯行TACE、替加氟1g连续静脉化疗4d、肝内转移瘤微波消融术；对照组35例，仅行XELOX或FOLFOX6方案静脉化疗。以患者缓解率、生存期作为评价指标。结果联合治疗组病情缓解率为64.9％，显著高于对照组28.6％，且联合组治疗后6个月、12个月、18个月、24个月生存率分别为100％、78.4％、48.7％、24.3％，较对照组明显延长。结论 TACE联合微波消融及静脉化疗治疗消化道肿瘤肝转移，是一种较安全有效的治疗方法。

The clinical observation on transcatheter arterial chemoembolization combined with microwave ablation and vein chemotherapy and the vein chemotherapy only in treatment of hepatic metastasis of malignant tumor from digestive tract

Objective To observe the clinical value of the TACE （transcatheter arterial chemoembolization ） combined with the microwave ablation and vein chemotherapy in treatment of hepatic metastasis of malignant tumor from digestive tract .Methods 72 patients who had no chance for operation or were not willing to accept the operation were selected ,were randomly divided into the combination group and control group .The combination group were given the combined therapy of TACE ,vein chemotherapy of tegafur for 4 days ,and then given the mi‐crowave ablation successively .The control group was only given the vein chemotherapy .The response rate and survival time were measured .Results The response rate of combination group was 64 .9% ,which was higer than the control group （28 .6% ） .The overall survival at 6 months ,12months ,18 months ,24months were 100% , 78.4% ,48.7% ,and 24.3% ,respectively in the combination group ,which was longer than control group signifi‐cantly .Conclusion The combination of TACE with microwave ablation and vein chemotherapy plays an important role in treating hepatic metastasis of malignant tumor from digestive tract ,which is safe and effective .