| 7-羟基黄酮木糖苷及7-羟基黄酮鼠李糖苷的合成研究 |
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| 引用本文： | 郭瑞霞,张宝华,吕立强,史兰香.7-羟基黄酮木糖苷及7-羟基黄酮鼠李糖苷的合成研究[J].河北化工,2010,33(7):14-15,23. |
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| 作者姓名： | 郭瑞霞 张宝华 吕立强 史兰香 |
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| 作者单位： | 石家庄学院,河北,石家庄,050035 |
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| 基金项目： | 石家庄市科技支撑项目 |
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| 摘 要： | 以溴代乙酰糖和7-羟基黄酮为原料,使用较弱的碱（1 mol/L KCl的NaHCO3溶液）,采用相转移催化法以较高的收率合成了7-羟基黄酮木糖苷（1）和7-羟基黄酮鼠李糖苷（2）。考察了反应方式、温度、投料比对糖苷化反应收率的影响,最佳反应条件为n（7-羟基黄酮）∶n（溴代乙酰糖）=1∶1.6,丙酮溶液中40℃反应15 h,收率分别达到64%和59%。化合物（1）和（2）的结构经IR1、H-NMR、EI-MS表征。
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| 关 键 词： | 黄酮糖苷 相转移催化 合成 |
Synthesis of 7-Hydroxyflavone Xyloside and 7-Hydroxyflavone Rhamnoside |
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| GUO Rui-xia,ZHANG Bao-hua,LV Li-qiang,SHI Lan-xiang.Synthesis of 7-Hydroxyflavone Xyloside and 7-Hydroxyflavone Rhamnoside[J].Hebei Chemical Engineering and Industry,2010,33(7):14-15,23. |
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| Authors: | GUO Rui-xia ZHANG Bao-hua LV Li-qiang SHI Lan-xiang |
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| Affiliation: | (Shijiazhuang University,Shijiazhaung 050035,China) |
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| Abstract: | 7-Hydroxyflavone xyloside and 7-hydroxyflavone rhamnoside were synthesized by phase transfer catalysis from bromo-acetyl-sugar and 7-hydroxyflavone in the presece of weak base 1 mol/L KCl/NaHCO3.The effects of reaction conditions such as reaction methods,reaction temperature and the molar ratio of materials on reaction yield were studied.The opti-mal reaction conditions were as follows： ratio of 7-hydroxyflavone to bromo-acetyl-sugar is 1∶1.6,reaction time is 15 h,reaction tempreture is 40 ℃ and acetone as solvent.The yield of the reaction reached 64% and 59%.The stuctures were conformed by IR,1H-NMR and MS. |
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| Keywords: | phase transfer catalysis flavone-glycoside synthesis |
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