意外抗体筛查检出抗“Mur”抗体的临床意义

目的通过对＂Mur＂抗原的制备研究,探讨意外抗体筛查检出抗＂Mur＂抗体的临床意义,为临床选择合适的血液,预防输血反应,确保有效输血及输血安全。方法首先用含Mur抗原谱细胞筛查出抗＂Mur＂抗体,然后用该抗＂Mur＂抗体制备＂Mur＂抗原作为4号筛查细胞,用于输血前的意外抗体筛查。结果 8 200例抗体筛查中抗＂Mur＂抗体阳性68例,阳性率为0.83%。该68例患者中,33例有反复输血史,26例有妊娠史,由于产生意外抗体而引起疑难配血者38例。结论意外抗体筛查检出抗＂Mur＂抗体能有效提高临床输血安全,具有重要的临床价值。

Clinical significance of unexpected antibody screening with detection of anti-Mur antibody

Objective To investigate the clinical significance of unexpected antibody screening with detection of anti-Mur antibody by preparation of Mur antigen, for the purpose of selecting the appropriate blood for clinical transfusion, preventing the transfusion reaction and assuring the safety and efficiency in clinical transfusion. Methods First, with panel cells containing Mur antigen, we screened out anti-Mur antibody. Then, we prepared the Mur antigen as new sieve cells used in unexpected blood screening before transfusion. Results Totally 68 （0.83%） samples were positive among 8 200 samples by antibody screen test. Of the 68 cases, 33 cases had a history of repeated transfusion, 26 cases had a history of pregnancy and 38 eases had difficulty of blood matching because of the unexpected antibody. Conclusion Screening of unexpected antibody （anti-Mur） could effectively improve the safety of clini- cal transfusion, which is of great clinical value.