中青年血清胆红素轻度增高者胆红素与血糖、血脂及血压的关系

目的观察中青年血清胆红素轻度增高者血糖、血脂及血压水平。方法中青年男女556人，高胆红素组296人，对照组260人。测定两组研究对象血清总胆红素、直接胆红素、空腹血糖、总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇及血压并对数据进行分析。结果男性胆红素高于女性，差异有统计学意义（P〈0．01）。高胆红素组空腹血糖低于对照组，男性二组差异有统计学意义（P〈0．01），女性二组差异无统计学意义（P〉0．05）。高胆红素组收缩压低于对照组，但差异无统计学意义（P〉0．05），舒张压高于对照组，且差异有统计学意义（P〈0．05）。高胆红素组男性总胆固醇、甘油三酯高于对照组，高及低密度脂蛋白胆固醇低于对照组，其中高密度脂蛋白胆固醇与对照组差异有统计学意义（P〈0．05）。高胆红素组女性总胆固醇、甘油三酯、高与低密度脂蛋白胆固醇均高于对照组，但差异无统计学意义（P〉0．05）。空腹血糖与男性总胆红素、直及间接胆红素和女性直接胆红素负相关。舒张压与男性总胆红素及直接胆红素和女性总胆红素及间接胆红素正相关；收缩压与男性胆红素不相关，与女性直接胆红素负相关。男性低密度脂蛋白胆固醇、女性总胆固醇、腰围与直接胆红素负相关。男性腰围与总胆红素、间接胆红素正相关。结论胆红素不同形式对空腹血糖均有影响，中青年阶段空腹血糖随着胆红素的增高而降低。胆红素对中青年男女舒张压的维持有一定作用，对收缩压的影响有性别差异，女性胆红素较高者，舒张压较低。中青年男女在高胆红素水平时有较少的心脑血管危险因素。

Levels of fasting plasma glucose, lipoprotein, and blood pressure in the young and middle-aged with a mildincrease in serum bilirubin

Objective To observe the levels of fasting plasma glucose, lipoprotein, and blood pressure in the young and middle-aged with a mild increase in serum bilirubin. Methods 556 young and middle-aged people were divided into a group with mild increase of serum bilirubin （n=296） and a control group （n=260）. The T-Bili, D-Bili, fasting plasma glucose, TC, TG, HDL-C, LDL-C, and blood pressure of all study objects were determined and then their results were analyzed. Results The serum bilirubin was higher in the male than in the female, with a statistical difference （P〈 005 ） . The FPG and SBP were lower and DBP was higher in the group with mild increase of serum bilirubin than in the control group, with a statistical difference in FPG between the males but no statistical difference between the females of the 2 groups and a statistical difference in DBP between the 2 groups. The TC and TG were higher and HDL-C and LDL-C were lower in the male of the group with mild increase of serum bilirubin than in the male of the control group, with a statistical difference in HDL-C. The TC, TG, HDL-C, and LDL-C were higher in the female of the group with mild increase of serum bilirubin than in the female of the control group, with no statistical difference. FPG negatively correlated with T-Bili and D-Bili in male and with D-Bili in female. DBP positively correlated with T-Bili and D-Bili in male and with T-Bili and indirect bilirubin in female. SBP negatively correlatedwith D-Bili in female but with noting in male. The LDL-C of male and the TC and waistline of female negatively correlated with D-Bili The waistline of male positively vorrelated with T-bili and indirect bilirubin. Conclusions Increasing with serum bilirubin, the level of FPG decreases in young and middle-aged people. Bilirubin may be beneficial to maintain the level of DBP in the young and middle-aged. There is a gender difference in the influence on SBP. The female with higher level of bilirubin have lower DBP. There are fewer risk factors of cardiovascular and cerebrovascular in the young and middle-aged people with a mild increase of bilirubin.