A p50 surface antigen restricted to human urinary bladder carcinomas and B lymphocytes |
| |
Authors: | Staffan Paulie Barbro Ehlin-Henriksson Håkan Mellstedt Hannu Koho Hedi Ben-Aissa Peter Perlmann |
| |
Affiliation: | (1) Department of Immunology, University of Stockholm, S-106 91 Stockholm, Sweden;(2) Department of Tumor Biology, Karolinska Institute, S-10401 Stockholm, Sweden;(3) Radiumhemmet, Karolinska Hospital, S-10401 Stockholm, Sweden |
| |
Abstract: | Summary We have previously described the derivation of a monoclonal antibody, S2C6, to a novel 50 Kdalton antigen associated with human urinary bladder carcinoma. No reactions were obtained with carcinomas of unrelated origin or with normal urothelial cells. However, the antibody also reacted with a similar antigen on some cell lines of B lymphocyte origin. Using large panels of target cells we have now shown that this reactivity was entirely restricted to cells of the B lineage within the haematopoietic system. As opposed to its apparent restriction to malignant cells of the urothelium, the S2C6 antigen was expressed by normal B lymphocytes as well as by many malignant B cells (chronic lymphocytic leukaemia, hairy cell leukaemia and immunocytoma). Pre-B cells derived from acute lymphocytic leukaemia and plasma cells from multiple myeloma lacked the antigen. Expression was significantly enhanced on cultured B cells from Burkitt lymphomas and on Epstein-Barr virus-transformed lymphoblastoid cell lines including those of the pre-B phenotype derived from fetal bone marrow. As judged from the molecular size and the distribution pattern displayed by the S2C6 antigen it appears to be distinct from other B cell antigens previously described. A possible relation of the S2C6 antigen to a receptor for B cell growth factors is discussed. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|