| 黄磷对大鼠肝微粒体和线粒体Ca^2＋泵的影响 |
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| 引用本文： | 廖肇浩,周炯亮.黄磷对大鼠肝微粒体和线粒体Ca^2＋泵的影响[J].中华劳动卫生职业病杂志,1991,9(4):216-219. |
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| 作者姓名： | 廖肇浩 周炯亮 |
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| 作者单位： | 江西医学院劳动卫生教研室 南昌330006
(廖肇浩)，中山医科大学劳动卫生教研室 广州510089(周炯亮) |
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| 摘 要： | 在体外实验中,用不同浓度黄磷(0.026μg/ml,0.26μg/ml,2.60μg/ml)与大鼠肝微粒体和线粒体共同孵育,发现黄磷对肝微粒体和线粒体Ca~(2 )-ATP酶呈现抑制作用,且随剂量增大,抑制作用加重;在孵育的早期,对微粒体Ca~(2 )ATP酶的抑制更明显。在整体动物实验中,黄磷染毒后6小时,对肝微粒体和线粒体Ca~(2 )-ATP酶发生抑制。染毒后3小时,对肝微粒体~(45)Ca摄取发生抑制;染毒后6小时,对肝线粒体~(45)Ca摄取发生抑制。实验结果表明,黄磷对微粒体和线粒体Ca~(2 )泵机制的损害可能是引起中毒性肝损害的一个重要因素。
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| 关 键 词： | 黄磷 肝微粒体 肝线粒体 Ca~(2 )-ATP酶 ~(45)Ca摄取 中毒性肝损害 |
Effects of Phosphorus on the Calcium-pumps of Rat Microsome and Mitochondria |
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| Liao Zhao-hao,et al/.Effects of Phosphorus on the Calcium-pumps of Rat Microsome and Mitochondria[J].Chinese Journal of Industrial Hygiene and Occupational Diseases,1991,9(4):216-219. |
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| Authors: | Liao Zhao-hao / |
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| Abstract: | In vitro,rat liver microsome and mitochondria incubated with variousconcentrations of yellow phosporus,showed that their Ca~(2 )-ATPase wereinhibited in a dose-dependant manner.In vivo,the inhibitive role of yellowphopsporus on liver microsome and mitochondria was observed 6h.after dos-ing and the inhibition of Ca~(2 )-uptake of microsome and mitochondria 3h.and6h.after dosing respectively.These results suggested that the impairment ofCalcium-pumps of liver microsome and mitochondria was an important fac-tor in the liver injury induced by yellow phosphorus. |
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| Keywords: | Yellow Phosphorus Liver microsome Liver mitochondria Ca~(2 )-ATPase Calcium-uptake Toxic liver injury |
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