| 脑外伤合并股骨骨折后leptin对骨折愈合的实验研究 |
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| 引用本文： | 姚翔,汪雷,章洪喜.脑外伤合并股骨骨折后leptin对骨折愈合的实验研究[J].齐齐哈尔医学院学报,2011,32(1):1-3. |
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| 作者姓名： | 姚翔 汪雷 章洪喜 |
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| 作者单位： | 江苏大学附属人民医院骨科,212001 |
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| 摘 要： | 目的研究大鼠股骨骨折合并脑外伤时血清leptin水平及骨痂组织中leptin的表达,探讨leptin与骨折合并脑外伤时骨折愈合加快的关系方法将64只SD大鼠随机分为四组：对照组、脑外伤组、骨折组和骨折合并脑外伤组各16只。建立大鼠中度脑损伤和骨折模型,分别于1、2、4、8﹑12周取血清,放射免疫法测血清中leptin水平,骨折标本摄X线片,骨痂组织作免疫组化。结果第2,4,8周与对照组相比骨折并脑外伤组、脑外伤组、骨折组大鼠血清leptin浓度均有显著性增高（P〈0.05）;第4周时骨折并脑外伤组大鼠血清leptin升高水平较其它两组明显（P〈0.05）;从第8周开始,手术3组大鼠血清leptin浓度都有所下降,但骨折并脑外伤组leptin浓度仍明显高于其它两组（P〈0.05）;第12周各组之间无统计学差异（P〉0.05）。脑外伤合并骨折组形成骨痂体积在X线片上高于单纯股骨骨折组,差异有显著性（P〈0.05）。骨折合并脑外伤组中骨痂组织leptin免疫组化染色平均阳性细胞数比骨折组有显著性增加（P〈0.05）。结论伴有脑外伤的骨折愈合过程中,在一定时间内血清leptin水平升高,骨折愈合加快,提示Leptin是脑外伤后骨折愈合加速的因素之一。
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| 关 键 词： | 瘦素（leptin） 脑损伤 股骨骨折 骨痂 |
Experimental study on the relationship between leptin and enhanced osteogenesis after brain injury |
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| YAO Xiang,et al..Experimental study on the relationship between leptin and enhanced osteogenesis after brain injury[J].Journal of Qiqihar Medical College,2011,32(1):1-3. |
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| Authors: | YAO Xiang |
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| Affiliation: | YAO Xiang,et al.(Orthopedics Department,the People's Hospital Affiliated to Zhejiang University,Zhejiang 212001,the P.R.China) |
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| Abstract: | Objective To study the relationship between leptin and enhanced osteogenesis after brain injury by investigating the expression of leptin in callus and the level of leptin in serum of rats with brain injury and femoral fracture.Methods 64 male SD rats were randomly divided into 4 groups:normal control,brain injury group,fracture group,fracture with brain injury group(n =16 per group).Fracture and brain injury models were established.The rats were sacrificed 2,4,8and12weeks respectively after operation,and t... |
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| Keywords: | Leptin Brain injury femoral fracture Callus formation |
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