6-(1-Alkenoyloxyalkyl)-5,8-dimethoxy-1,4-naphthoquinone derivatives: Synthesis and evaluation of antitumor activity |
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Authors: | Young-Jae You Byung-Zun Ahn |
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Affiliation: | (1) College of Pharmacy, Chungnam National University, 305-764 Taejon, Korea |
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Abstract: | Thirty six 5,8-dimethoxy-1,4-naphthoquinone derivatives, which bear unsaturated alkyl side chain with ester bond, were synthesized
and tested cytotoxic activity on L1210 cells and antitumor activity against ICR mice bearing S-180 cells. It could be recognized
that the cytotoxicities of naphthoquinones with R1 being methyl and propyl (IV1∼24) were not enhanced by replacing the alkanoyls with alkenoyls. In contrast, the introduction of the alkenoyl moieties on the
compounds with R1=hexyl (IV25∼36) resulted in the enhancement of their cytotoxicities. Replacement of alkanoyl group with an alkenoyl group generally increased
the T/C value of the mice bearing S-180 cells. |
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Keywords: | Key word" target="_blank">Key word 6-Substituted 5 8-dimethoxy-1 4-naphthoquinone Esters of alkenoic acids Antitumor activity |
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