血清CEA、CA125、CYFRA21-1、CT联检对肺癌诊断的意义

目的 探讨血清CEA、CA125、CYFRA21-1、CT联检与肺癌临床诊断的相关性.方法 采用放射免疫分析法与电化学发光法对58例肺癌患者和30例正常健康人进行血清标本测定.结果 肺癌组CEA、CA125、CYFRA21-1、CT均高于正常对照组(P<0.01),CEA腺癌组的阳性率明显高于鳞癌组和小细胞癌组(P<0.01),CA125腺癌组、小细胞癌组阳性率明显高于鳞癌组(P<0.01),CYFRA21-1在鳞癌中的阳性率高于腺癌组和小细胞癌组(P<0.01),CT在鳞癌、腺癌、小细胞癌的阳性率,无明显差异(P>0.05).肺癌患者血清CEA、CA125、CYFRA21-1、与CT水平成正相关.结论 CEA、CA125、CYFRA21-1、与CT联检可互补,提高肺癌诊断阳性率.

Significance of combined detection of serum CEA, CA125, CYFRA21-1, CT lung cancer

Objective:To study the value of blood serum CEA,CA125,CYFRA21-1,CT.Methods: By using emission immunity analytic method and electrochemistry illumination to test the blood serum for CEA,CA125,CYFRA21-1 and CT in 58 lung cancer patient and 30 normal healthy personses.Results: In lung cancer group,CEA,CA125,and CYFRA21-1,and CT were higher than normal group(P<0.01),CEA in glands cancer group was higher than squamous cell cancer group and small cell cancer group(P<0.01),CA125 in glands cancer group and small cell cancer group positive rate obvious than squamous cell cancer group(P<0.01),CYFRA21-1 in squamous cell cancer than glands cancer group and small cell cancer group(P<0.01),CT in squamous cell cancer,glands cancer,small cell cancer was similar(P>0.05).Serum CEA,CA125,CYFRA21-1,and CT level was positively related.Conclusion: CEA,CA125,CYFRA21-1,and CT can enhance the clinical diagnosis positive rate of lung cancer.