Reactive glial protein synthesis and early disappearance of saxitoxin binding in degenerating rat optic nerve |
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Authors: | Michael J Politis Richard G Pellegrino Anne Louise Oaklander J Murdock Ritchie |
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Affiliation: | Department of Pharmacology, University of Illinois at Chicago, Chicago, IL 60612, U.S.A. |
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Abstract: | Rats implanted with EEG and EMG electrodes were treated with deoxycoformycin (0.5 or 2.0 mg/kg, i.p.), and polygraphically recorded for 6 h. Deoxycoformycin is a potent inhibitor of adenosine deaminase and would be expected to elevate the levels of adenosine in the central nervous system. The 0.5 mg/kg dose of the drug increased REM sleep and reduced REM sleep latency while the dose of 2.0 mg/kg increased deep slow-wave sleep (S2). These results appear to be consistent with those reported previously for the adenosine analog, N6-(L-phenylisopropyl)-adenosine (L-PIA) and indicate a hypnotic role for adenosine. |
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Keywords: | gliosis nerve degeneration |
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