胃癌组织中p-mTOR表达与患者预后的关系

目的探讨中国人胃癌组织中哺乳动物雷帕霉素靶蛋白（mTOR）的活化形式p—mTOR蛋白的表达与胃癌预后的关系。方法采用免疫组化方法检测181例胃癌组织中P—mTOR蛋白的表达情况，分析其与胃癌预后的关系。单因素分析采用Kaplan—Meier法计算患者存活率并比较平均生存时间，多因素分析用COX回归模型。结果181例胃癌标本中p—mTOR蛋白表达阳性93例，阳性表达率为51．4％。与p—mTOR表达阴性患者比较，其阳性患者的患者总存活率与无病存活率明显缩短（组间比较DFS，P〈0．01；OS，P〈0．05）。多因素分析结果显示，p-mTOR的表达与预后呈负相关。结论胃癌组织中p—mTOR蛋白的表达是影响胃癌预后的因素之一。

Prognosis significance of p-mTOR expression in gastric cancer

Objective To investigate the prognostic significance of activated mTOR （p-roTOR） expression in gastric cancer patients undergoing curative surgery. Methods The expression of p-mTOR was detected in specimens of 181 gastric cancers who underwent radical resection （R0） by immunohistochemistry. The influence of each variable on survival was analyzed by the multivariate analysis of Cox proportional hazard model. Results The positive rate of p-mTOR in gastric cancer was 51.4%. Patients with p-mTOR positive showed significantly shorter disease-free survival （DFS） and overall survival （OS） rates than those with p-mTOR-negative tumors in univariate analyses （DFS, P 〈 0.01 and OS, P 〈 0.05, respectively）, and there was a trend toward a correlation between p-mTOR expression and survival in multivariate analyses （DFS, P =0.059 and OS, P =0.07, respectively）. Conclusion The expression of roTOR actived is associated with poor prognosis in patients with gastric cancer underwent curative surgery.