| 后基因组时代的药物发现:趋势和实践 |
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| 引用本文： | 陈凯先,蒋华良,罗小民,沈建华.后基因组时代的药物发现:趋势和实践[J].中国天然药物,2004,2(5):257-260. |
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| 作者姓名： | 陈凯先 蒋华良 罗小民 沈建华 |
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| 作者单位： | 中国科学院上海药物研究所,上海,201203 |
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| 摘 要： | 人类基因组计划深刻地影响了药物研究和开发的思路和策略，生命科学的研究方法和技术与药物研究的结合日益紧密，计算机信息技术也越来越多应用到药物研究过程中来。本文以实例说明了虚拟筛选、配体垂钓以及靶标的发现与确证方法在药物研究中的应用。
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| 关 键 词： | 药物研究 药物发现 虚拟筛选 后基因组时代 靶标 配体垂钓 |
| 文章编号： | 1672-3651(2004)05-0257-04 |
| 修稿时间： | 2004年8月20日 |
Drug Discovery in Post-genome Era:Trend and Practice |
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| CHEN Kai Xian,JIANG Hua Liang,LUO Xiao Min,SHEN Jian Hua Shanghai Institue of Materia Medica,Chinese Academy of Sciences,Shanghai ,China.Drug Discovery in Post-genome Era:Trend and Practice[J].Chinese JOurnal of Natural Medicines,2004,2(5):257-260. |
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| Authors: | CHEN Kai Xian JIANG Hua Liang LUO Xiao Min SHEN Jian Hua Shanghai Institue of Materia Medica Chinese Academy of Sciences Shanghai China |
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| Affiliation: | CHEN Kai Xian,JIANG Hua Liang,LUO Xiao Min,SHEN Jian Hua Shanghai Institue of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China |
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| Abstract: | The progresses from Human Genome Project have dramatically changed the strategy and methods of drug discovery and development.Meanwhile,new methods and techniques from life sciences and computer informatics have been also introduced into drug discovery.Here we demonstrate the applications of virtual screening,ligand fishing and drug target validation to drug study. |
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| Keywords: | Genome Systems biology High content screening Virtual screening Ligan fishing Drug target validation |
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