广州市儿童维生素D水平及其与甲状旁腺素的关系

了解广州市儿童维生素D水平及其与甲状旁腺素(PTH)的关系,为减少儿童维生素D缺乏性疾病的发生和改善儿童骨骼健康提供科学依据.方法 采用横断面研究,对2015年广州市某妇幼保健院健康体检的976名儿童进行体格检查,采集空腹静脉血,用化学发光法检测血清25-羟维生素D25(OH)D]和甲状滂腺素(PTH).结果 儿童血清25(OH)D平均水平为(90.67±36.55) nmol/L,其中男童为(90.14±34.89) nmol/L,女童为(91.33±38.58) nmol/L,差异无统计学意义(P>0.05).维生素D缺乏率及不足率分别为11.37%和25.31%,性别间差异无统计学意义(P>0.05).不同年龄儿童血清25(OH)D水平差异有统计学意义(F=55.547,P<0.05),血清25(OH)D水平随年龄增长呈下降趋势.不同年龄儿童维生素D营养状况差异有统计学意义(x2=87.352,P< 0.05),维生素D缺乏率及不足率随年龄增长而升高(x2趋势=68.909,P<0.05).儿童血清PTH平均水平为(2.38±1.29) pmol/L,维生素D缺乏及不足儿童血清PTH水平均高于维生素D充足儿童,差异有统计学意义(F=10.427,P<0.05).血清25(OH)D水平与PTH呈负相关(r=-0.149,P=0.000).结论 广州市0~16岁儿童维生素D缺乏率及不足率较高,年长儿童维生素D营养状况较年幼儿童差,血清25(OH)D与PTH水平呈负相关.应采取合理措施改善儿童维生素D的营养状况.

Relationship between concentration of vitamin D and parathyroid hormone among children in Guangzhou

Objective To understand the relationship of concentration of vitamin D and parathyroid hormone (PTH) of children in Guangzhou,providing early indicators for vitamin D deficiency.Methods Physical examination and laboratory tests were carried out among children in Guangzhou in a cross-sectional survey.Chemiluminescence was used to detect the levels of serum 25-hydroxy vitamin D 25(OH)D and PTH.Results The average serum 25(OH)D concentration was (90.67±36.55) nmol/L,there was no significant difference on serum 25 (OH) D concentration between boys and girls (P>0.05).The prevalence of vitamin D deficiency and insufficiency was 11.37% and 25.31%,respectively,no significant differences were found between boys and girls(P> 0.05).The serum 25(OH) D concentration related with age.With increase of age,the serum 25(OH) D concentration decreased(P <0.05),the prevalence of vitamin D deficiency and insufficiency increased (P<0.05).The average serum PHT concentration was (2.38± 1.29) pmol/L.The serum PTH concentration in vitamin D deficiency or insufficiency was higher than that in vitamin D sufficiency (P<0.05),negative correlation was found between 25 (OH) D and PTH (P<0.01).Conclusion The prevalence of vitamin D deficiency and insufficiency is high in children aged 3-16 years old in Guangzhou,serum 25(OH)D concentration negatively correlates with PTH.Comprehensive measures should be taken to improve the status of vitamin D of children.