JAK-STAT通路在糖尿病肾病中的作用及中药干预的研究进展

Research progress on JAK-STAT pathway in diabetic nephropathy and intervention effect of traditional Chinese medicine

Diabetic nephropathy (DN) is one of the main microvascular complications of diabetes, and also an important cause of end-stage renal disease. Many factors are involved in the occurrence of DN. Among them, JAK-STAT can cause renal inflammatory injury by promoting the expression of inflammatory factors and inducing the activation of inflammatory cells, and it plays an important role in the occurrence and development of DN. A large number of literature studies have shown that traditional Chinese medicine had obvious advantages in the prevention and treatment of DN. Some traditional Chinese medicine or their extracts can regulate JAK-STAT signaling pathway, thereby improving the renal tissue inflammatory injure of DN, and then exerting a renal protective effect. In this paper, the research progress of JAK-STAT signaling pathway in DN and the intervention effect of traditional Chinese medicine in recent years is reviewed, in order to provide a reference for its in-depth study.