| 2-乙氧亚胺基-2-(5-氨基-1,2,4-噻二唑-3-基)乙酸的合成 |
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| 引用本文： | 苏慧霞,王 琪,陈爱莲. 2-乙氧亚胺基-2-(5-氨基-1,2,4-噻二唑-3-基)乙酸的合成[J]. 河北工业科技, 2008, 25(6): 361-362,370 |
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| 作者姓名： | 苏慧霞 王 琪 陈爱莲 |
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| 作者单位： | 石家庄以岭药业股份有限公司质检科,河北石家庄,050035;石家庄科技信息职业学院医药工程系,河北石家庄,050091;石家庄欧意药业有限公司一车间,河北石家庄,050051 |
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| 摘 要： | 2-乙氧亚胺基-2-(5-氨基-1,2,4-噻二唑-3-基)乙酸类化合物多用于新型头孢菌素类药物的合成,确定了其合理的工艺路线,以氰基乙酰胺为原料,经肟化、烷基化、三氯氧磷脱水、氨解、溴代、环合、碱性水解得到目标产物。
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| 关 键 词： | 杂环化合物 2-乙氧亚胺基-2-(5-氨基-1 2 4-噻二唑-3-基)乙酸 头孢菌素 |
| 收稿时间： | 2008-06-24 |
| 修稿时间： | 2008-09-12 |
Synthesis of 2-(5-amino-1,2,4-thiadiazol-3-yl)-2-alkoxyimino acetic acid |
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| SU Hui-xi,WANG Qi and CHEN Ai-lian. Synthesis of 2-(5-amino-1,2,4-thiadiazol-3-yl)-2-alkoxyimino acetic acid[J]. Hebei Journal of Industrial Science & Technology, 2008, 25(6): 361-362,370 |
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| Authors: | SU Hui-xi WANG Qi CHEN Ai-lian |
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| Affiliation: | SU Hui-xia1,WANG Qi2,CHEN Ai-lian3(1.Quality Test Department,Shijiazhuang Yiling Pharmaceutical Company Limited,Shijiazhuang Hebei 050035,China,2.Medical Engineering Department,Shijiazhuang Vocation College of Science , Technology Information,Shijiazhuang Hebei 050091,3.No.1 Workshop,Shijiazhuang Ouyi Pharmaceutical Company Limited,Shijiazhuang Hebei 050051,China) |
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| Abstract: | 2-(5-amino-1,2,4-thiadiazol-3-yl)-2-alkoxylimino acetic acid is applied in the preparation of novel cephalosprins.A reasonable synthetic route was designed,in which cyanoacetamide was used as starting material,then through oximation,alkylation,aminolysis,bromation,cyclization with postassium thiocyanate,hydrolysis in base environment,to obtain 2-(5-amino-1,2,4-thiadiazol-3-yl)-2-alkoxyimino acetic acid. |
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| Keywords: | heterocyclic compound 2-(5-amino-1 2 4-thiadiazol-3-yl)-2-alkoxyimino acetic acid cephalosporins |
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