选择脱卤还原反应的研究

Ramasamy、Osuka等用NaHTe/EtOH研究了二卤代物的脱邻二溴、偕二溴反应和α-溴代羰基化合物的脱卤还原反应,我们选择结构不同的卤代物以NaHTe还原,发现在水介质和催化量碲代替计算量碲时也能顺利地进行这类反应,其反应条件温和,产率高,是有机官能团转化的好方法。

Studies on the Selective Dehalogenation Reduction Reaction

Various halogen compounds were effectively reduced by sodium hydrogen telluride in aqueous solution or ethanol under mild conditions and in good yields, particularly when a molecule contains other groups such as carbonyl, carboxyl, ester and benzyl.The typical process occurred with a stbichiometric amount or a catalytic amount of tellurium. The mechanism may be envisaged that nucleophilic attack of hydrogen telluride ion (HTe-)-on the a-car-bon atoms could lead to the leaving of the halogen from a-carbon atoms.