参百润肺胶囊急性毒性实验研究

目的：探讨参百润肺胶囊对小鼠的急性毒性反应。方法：实验前禁食不禁水12 h,参百润肺胶囊组按小鼠可灌服的最大体积（0.04 mL/g）灌服最大可灌服浓度的参百润肺胶囊混悬液（0.5 g/mL）;生理盐水组小鼠灌服最大体积（0.04 mL/g）的生理盐水。灌胃,3次/d,每次间隔8 h,然后给动物以正常饮食,连续观察14 d。结果：小鼠未出现死亡。结论：小鼠每日积累最大耐受量为60 g原生药/kg,该量已为临床用量的460倍以上,可以认为临床用药安全。

Experimental Study of the Acute Toxicity of Shenbai Runfei Capsule

Objective：To study the acute toxicity reaction of mice when they are given Shenbai runfei capsules.Methods：All mice only took water without food for 12 h before experiment.The group of mice which were given Shenbai Runfei Capsule were irrigated mixed Shenbai Runfei suspension with the maximum PH indicator（0.5 g/mL）according to mice’s maximum volume of stomach-pouring（0.04 mL/g）;the group of mice which were given NS were irrigated the maximum volume NS（0.04 mL/g）,three times a day,8h for every interval;then all mice were given normal food intake,and continuously observed for 14 d.Results：No death was found in the mice.Conclusion：The maximum accumulated tolerable dosage of mice is 60 g/kg of the crude drugs per day,which is more than 460 times of the clinical dosage.The drug is considered safe in clinical application.