冠心病心绞痛中医辨证分型与NO、ET关系的探讨

目的:探讨NO、ET与冠心病心绞痛中医辨证分型的关系。方法:用硝酸还原酶法、放免法对60例不同证型冠心病心绞痛患者血浆NO和ET分别进行临床检测,并与20例正常人比较。结果:血浆NO水平依次为心血瘀证<心气虚证、心阴虚证<正常对照组(P<0．01,P<0．05);血浆ET水平依次为心血瘀证>心阴虚证、心气虚证>正常对照组(P<0．01,P<0．05)。结论:NO含量和ET含量与冠心病心绞痛中医证型有一定内在联系,可作为冠心病心绞痛辨证分型的的客观指标之一。

On Relationship of Nitric Oxide and Endothelin and Syndrome Differentiation of TCM in Coronary Heart Disease with Angina Pectoris

Objective:To investigate the relationship of NO and ET syndrome differentiation of traditional Chinese medicine in coronary heart disease with angina pectoris. Methods:The levels of serum NO and ET in the 60 patients with angina pectoris of coronary heart disease were detected with the nitrate reductase method and radio-immunity in clinic, and the 20 normal persons were compared. Results: The NO levels were lower in the syndrome of heart blood stasis than that in the syndrome of heart qi deficiency, lower in the syndrome of heart yin deficiency than that in the syndrome of heart qi deficiency normal group (P<. 0. 01 or P<0. 05) ; the ET level was higher in the syndrome of heart blood stasis than that in the syndrome of heart yin deficiency, higher in the syndrome of heart qi deficiency than that in the normal group(P< 0. 01 or P<0. 05). Conclusion:The volume of NO and ET is related to the syndrome differentiation of angina pectoris and can be as the objective parameters of the syndrome differentiation in clinic.