Impact of lymph node metastasis on survival in patients with pathological T1 carcinoma of the ampulla of vater |
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Authors: | Hiroshi Terasawa MD Kazuhisa Uchiyama MD Masaji Tani MD Manabu Kawai MD Takeshi Tsuji MD Katsuyoshi Tabuse MD Yasuhito Kobayashi MD Katsutoshi Taniguchi MD Hiroki Yamaue MD |
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Affiliation: | (1) the Department of Surgery, Osaka Minami Medical Center, Osaka, Japan;(2) the Department of Surgery, Wakayama Rosai Hospital, Wakayama, Japan;(3) Second Department of Surgery, Wakayama Medical University, School of Medicine, 811-1 Kimiidera, 641-8510 Wakayama, Japan |
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Abstract: | To determine the prognostic factors for patients with pathological T1 (pT1) carcinoma of the ampulla of Vater, 36 consecutive
patients with carcinoma of the ampulla of Vater who underwent surgery were retrospectively analyzed in terms of clinicopathological
features. The overall 5-year Kaplan-Meier survival in all patients was 50.2%, and the median survival of all patients was
64.0 months. Factors favorably influencing a long-term outcome were the absence of lymph node metastasis (P<0.0001), the absence of ulcer formation of the tumor (P=0.0062), and the absence of tumor invasion into the duodenum (P = 0.0025) and the pancreas (P=0.0098). In a multivariate analysis, lymph node metastasis was the only predictor of survival (P=0.0023). In the pT1 stage patients, 20% of the patients had lymph node metastasis, and their survival was statistically poor
compared to the pT1 patients without lymph node metastasis (P=0.017). As for survival after the operation, there was no significant difference between pancreatoduodenectomy and pylorus-preserving
pancreatoduodenectomy. |
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Keywords: | Carcinoma of ampulla of Vater prognostic factor lymph node metastasis |
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