| Antitumor Metallothiosemicarbazonate： Synthesis,Crystal Structure,Spectra and Antitumor Studies of Co（Ⅲ） Complex with Thiosemicarbazone Derivative of 2-Benzoylpyridine |
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| 引用本文： | 李明雪,周静,王子梁,王敬平.Antitumor Metallothiosemicarbazonate： Synthesis,Crystal Structure,Spectra and Antitumor Studies of Co（Ⅲ） Complex with Thiosemicarbazone Derivative of 2-Benzoylpyridine[J].结构化学,2008,27(3):281-286. |
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| 作者姓名： | 李明雪 周静 王子梁 王敬平 |
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| 作者单位： | Institute of Molecular and Crystal Engineering College of Chemistry and Chemical Engineering，Henan University，Institute of Molecular and Crystal Engineering，College of Chemistry and Chemical Engineering，Henan University，Institute of Molecular and Crystal Engineering，College of Chemistry and Chemical Engineering，Henan University，Institute of Molecular and Crystal Engineering，College of Chemistry and Chemical Engineering，Henan University，Kaifeng 475001，China，Kaifeng 475001，China，Kaifeng 475001，China，Kaifeng 475001，China |
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| 基金项目： | the Natural Science Foundation of Henan Province (No. 0611011900)，the Foundation of Educational Department of Henan Province (No. 2007150012) |
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| 摘 要： | The title complex Co（L）2]Cl·4H2O I has been achieved via self-assembly by incorporating cobalt into 2-benzoylpyridine thiosemicarbazonate ligand, and characterized by elemental analysis, infrared spectra, mass spectra and single-crystal X-ray diffraction study. The crystal crystallizes in monoclinic, space group P2 1/n, with a = 10.227（3）, b = 17.363（4）, c = 17.459（4） A, β= 100.408（4）°, V= 3049.2（13） A^3, Z = 4, Mr = 677.08, Dc = 1.475 g/cm^3, μ（MoKα） = 0.834 mm^-1, F（000） = 1400, the final R = 0.0747 and wR = 0.0896 for 1663 observed reflections with I 〉 2σ（I）. The complex contains one six-coordinated cobalt ion connected by two thiosemicarbazone ligands which act as a tridentate ligand to coordinate with the center metal atoms via two pyridyl nitrogen atoms, two imine nitrogen atoms and two sulfur atoms giving rise to a mononuclear structure. Hydrogen bonds existing in the complex link the different components to stabilize the crystal structure. The antiturnor activity of the title complex was tested against A549 lung cancer cell line. Complex ! exhibits antitumor activity.
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| 关 键 词： | 抗癌药物 化学结构 晶体 生长工艺 |
Antitumor Metallothiosemicarbazonate： Synthesis,Crystal Structure,Spectra and Antitumor Studies of Co（Ⅲ） Complex with Thiosemicarbazone Derivative of 2-Benzoylpyridine |
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| LI Ming-Xue ZHOU Jing WANG Zi-Liang WANG Jing-Ping.Antitumor Metallothiosemicarbazonate： Synthesis,Crystal Structure,Spectra and Antitumor Studies of Co（Ⅲ） Complex with Thiosemicarbazone Derivative of 2-Benzoylpyridine[J].Chinese Journal of Structural Chemistry,2008,27(3):281-286. |
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| Authors: | LI Ming-Xue ZHOU Jing WANG Zi-Liang WANG Jing-Ping |
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| Affiliation: | Institute of Molecular and Crystal Engineering, College of Chemistryand Chemical Engineering, Henan University, Kaifeng 475901, China |
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| Abstract: | crystal structure, thiosemicarbazone, cobalt, cytotoxic activity |
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| Keywords: | crystal structure thiosemicarbazone cobalt cytotoxic activity |
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