新型脱氧胆酸类手性不对称脲分子钳的设计合成 |
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引用本文: | 赵志刚,刘兴利,李晖,唐晓丽.新型脱氧胆酸类手性不对称脲分子钳的设计合成[J].有机化学,2008,28(7):1233-1237. |
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作者姓名: | 赵志刚 刘兴利 李晖 唐晓丽 |
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作者单位: | 西南民族大学化学与环境保护工程学院,成都,610041 |
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基金项目: | 四川省应用基础研究,西南民族大学博士创新基金 |
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摘 要: | 以刚性的脱氧胆酸甲酯为隔离基, 在其3位连接苯甲酰基, 12位连接手性不对称脲, 设计合成了一类新型的手性分子钳. 其结构均经1H NMR, IR, MS和元素分析确证, 并且考察了其对中性分子和D/L-氨基酸甲酯的识别性能. 实验结果表明, 这类分子钳人工受体不仅对中性有机小分子具有良好的识别能力, 而且对D/L-氨基酸甲酯亦具有优良的对映选择性识别性能.
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关 键 词: | 脱氧胆酸 分子钳 合成 手性不对称脲 |
收稿时间: | 2008-3-8 |
修稿时间: | 2008-4-17 |
Design and Synthesis of Novel Deoxycholic Acid-Based Chiral Molecular Tweezers Containing Unsymmetrically Disubstituted Urea Unit |
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Affiliation: | (College of Chemistry and Environmental Protection Engineering, Southwest University for Nationalities, Chengdu 610041) |
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Abstract: | A novel type of chiral molecular tweezers has been designed and synthesized by linking benzoyl and chiral unsymmetrically disubstituted urea unit to 3-position and 12-position of rigid methyl deoxycholate. Their structures were confirmed by 1H NMR, IR, MS spectra and elemental analyses. The recognition properties of these molecular tweezers for neutral molecules and D/L-amino acid methyl esters have been investigated. The results indicate that these molecular tweezers not only recognize neutral organic molecules well, but also have good enantioselectivity for D/L-amino acid methyl esters. |
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Keywords: | deoxycholic acid molecular tweezer synthesis chiral unsymmetrical urea |
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