体外血栓形成机理的实验研究

血栓形成与流体力学因素关系密切，用健康成人血样进行的实验表明，Chandler血栓环内血液呈现出三维流动和二次流动状态，在管壁处的剪切应力最大。体外血栓形成应考虑血栓环弯曲和内部血液回流因素。血栓环内下弯月面处血栓的形成可能是流速相对较高的流体元冲击下弯月面导致血小板和红细胞聚集所至。当血栓环旋转时间低于10min时，血栓形成不良。15min是血栓形成的最佳时间。转速为3．75rpm时，不能形成血栓。

Experimental Studies on Mechanisms of Extracorporeal Thrombus Formation

Thrombus formation is closely related to hydrodynamical conditions. Fresh human blood in healthy donors was used for the experiments. The blood flow in Chandler's ring showed it is a three\|dimensional flow and of secondary conditions. The shear stress on the wall is the maximum. Both curvature of thrombus and blood reflux should be considered for extracorporeal thrombus formation. Results also showed that the cause of thrombus formed in lower menisucs may be the following one: The fluid element at relatively high speed strikes on lower meniscus, which leads to gathering of platelet and red blood cells. When the rotating time of thrombus ring was less than 10min, thrombus did not form well. 15min was the best time for thrombus formation. At rotating speed of 3\^75rpm, thrombus can't come in form.