| 含铁血黄素巨噬细胞与损伤时间的相关性研究 |
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| 引用本文： | 郑爱萍,胡金花,郑剑,李艳红,许小明. 含铁血黄素巨噬细胞与损伤时间的相关性研究[J]. 南昌大学学报(医学版), 2010, 50(7) |
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| 作者姓名： | 郑爱萍 胡金花 郑剑 李艳红 许小明 |
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| 作者单位： | 郑爱萍(北京大学深圳医院病理科,广东,深圳,518036;南昌大学基础医学院法医学教研室,南昌330006);胡金花(南昌大学基础医学院法医学教研室,南昌330006;新余市人民医院病理科,江西,新余,336500);郑剑,李艳红,许小明(南昌大学基础医学院法医学教研室,南昌330006;南昌大学司法医学鉴定研究所,南昌330006) |
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| 基金项目： | 江西省卫生厅科技计划项目 |
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| 摘 要： | 目的 研究小鼠皮肤损伤愈合过程中含铁血黄素巨噬细胞数量变化与损伤时间的关系,寻找推断损伤时间的病理形态学方法.方法 建立小鼠钝器创(挫裂创)和锐器创(切创)动物模型,应用普鲁士蓝染色法观察150只不同损伤时间小鼠伤后损伤区组织中的含铁血黄素巨噬细胞数量变化,同时以5只正常小鼠皮肤组织作对照.结果 在皮肤损伤区创缘组织中可见数量不等的含铁血黄素巨噬细胞,并随损伤时间的延长,呈现逐渐上升→高峰→逐渐下降的规律性变化.结论 应用普鲁士蓝染色法观察皮肤损伤区创缘组织中的含铁血黄素巨噬细胞数量变化,有望成为一种简便易行、经济实用的推断损伤时间的病理形态学方法.
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| 关 键 词： | 法医病理学 损伤时间推断 含铁血黄素巨噬细胞 普鲁士蓝染色 |
Relationship between Siderophages and Wound Age |
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| ZHENG Ai-ping,a,HU Jing-huaa,,ZHENG Jiana,b,LI Yan-honga,XU Xiao-minga,b. Relationship between Siderophages and Wound Age[J]. Journal of Nanchang University(Medical Science), 2010, 50(7) |
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| Authors: | ZHENG Ai-ping a HU Jing-huaa ZHENG Jiana b LI Yan-honga XU Xiao-minga b |
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| Affiliation: | ZHENG Ai-ping1,2a,HU Jing-hua2a,3,ZHENG Jian2a,2b,LI Yan-hong2a,XU Xiao-ming2a,2b(1.Department of Pathology,the Shenzhen Hospital of Peking University,Shenzhen 518036,China,2a.Department of Forensic Medicine,Basic Medical School,2b.Institute of Forensic Medicine,Nanchang University,Nanchang 330006,3.Department of Pathology,the People's Hospital of Xinyu,Xinyu 336500,China) |
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| Abstract: | Objective To observe the relationship between the number of siderophages and survival period after wounding during cutaneous wound healing in mice and to explore a practical method of pathology and morphology for wound age determination.Methods The mouse models of blunt instrument injury(laceration wound) and sharp instrument injury(incised wound) were established and Perls staining was used to detect the number of siderphages in wound tissue of 150 mice after wounding,and the skin of 5 normal mice served a... |
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| Keywords: | forensic pathology wound time determination siderophage Perls staining |
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