| Small interfering RNA inhibits SARS-CoV nucleocapsid gene expression in cultured cells and mouse muscles |
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| 引用本文： | Zhao P Qin ZL Ke JS Lu Y Liu M Pan W Zhao LJ Cao J Qi ZT. Small interfering RNA inhibits SARS-CoV nucleocapsid gene expression in cultured cells and mouse muscles[J]. 第二军医大学学报, 2005, 26(10): 1167-1167 |
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| 作者姓名： | Zhao P Qin ZL Ke JS Lu Y Liu M Pan W Zhao LJ Cao J Qi ZT |
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| 摘 要： | SARS-CoV isa newly identified coronavirus that causes severe acute respiratory syndrome （SARS）. Currently, there is no effective method available for prophylaxis and treatment of SARS-CoVinfections. In the present study, the influence of small interfering RNA （siRNA） on SARS-CoV nucleocapsid （N） protein expression was detected in cultured cells and mouse muscles. Four siRNA expression cassettes driven by mouse U6 promoter targeting SARS-CoV N gene were prepared, and their inhibitory effects on expression of N and enhanced green fluorescence protein （EGFP） fusion protein were observed.
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| 关 键 词： | RNA抑制作用 冠状病毒 非典型性肺疾病 基因表达 |
Small interfering RNA inhibits SARS-CoV nucleocapsid gene expression in cultured cells and mouse muscles |
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| Zhao;P;Qin;ZL;Ke;JS;Lu;Y;Liu;M;Pan;W;Zhao;LJ;Cao;J;Qi;ZT. Small interfering RNA inhibits SARS-CoV nucleocapsid gene expression in cultured cells and mouse muscles[J]. Former Academic Journal of Second Military Medical University, 2005, 26(10): 1167-1167 |
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| Authors: | Zhao P Qin ZL Ke JS Lu Y Liu M Pan W Zhao LJ Cao J Qi ZT |
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