| 辛酸─1—~(13)C的合成与分析 |
| |
| 引用本文： | 王惠琼,赵夏令,唐国忠.辛酸─1—~(13)C的合成与分析[J].核技术,2000(2). |
| |
| 作者姓名： | 王惠琼 赵夏令 唐国忠 |
| |
| 作者单位： | 中国科学院上海原子核研究所!上海２０１８００ |
| |
| 摘 要： | 将以溴代正庚烷为原料合成的格氏试剂溴化正庚基镁与Ｂａ１３ＣＯ３和浓Ｈ２ＳＯ４作用产生的１３ＣＯ２进行羧化反应，通过水解，提纯，制得辛酸─１─１３Ｃ，产率可达９０％─９３％。用薄层层析对其进行了定性分析，利用ＭＳ、ＩＲ、１Ｈ－ＮＭＲ和１３Ｃ－ＮＭＲ对其进行了结构分析和测定１３Ｃ丰度（８９．５％），并按口服药物的质量要求，用ＩＣＰ－ＡＥＳ和ＡＦＳ方法对有关金属元素进行了定量测定。
|
| 关 键 词： | 辛酸 碳─13 合成 分析 |
The synthesis and analysis of octanoic-1-~(13)C acid |
| |
| WANG Huiqiong, ZHAO Xialing ,TANG Guozhong.The synthesis and analysis of octanoic-1-~(13)C acid[J].Nuclear Techniques,2000(2). |
| |
| Authors: | WANG Huiqiong ZHAO Xialing TANG Guozhong |
| |
| Abstract: | A Grignard reagent prepared from n-heptyl bromide was carbonated with the carbon-1-~(13)C dioxide liberated from barium carbonate-1-~(13)C and concentrated sulfuric acid. The octanoic-1-~(13)C acid was obtained by acidic hydrolysis and purified by extraction. The yield was more than 90%. To analyze the structure and compute the ~(13)C abundance of the octanoic-1-~(13)C acid, various analysis of MS, IR, ~1H-NMR and ~(13)C-NMR were performed. According to the quality demand of the oral drug, the quantitative measurements of some metallic elements had also been carried out. |
| |
| Keywords: | Octanoic acid Carbon-13 Synthesis Analysis |
| 本文献已被 CNKI 等数据库收录！ |
