抑郁症患者血小板活化功能的临床研究

目的 探讨抑郁症患者血小板活化因子CD62p、CD63的表达和血浆血小板第4因子(PF4)的水平,寻求抑郁症与血小板活化之间的关系.方法 以36例抑郁症患者为研究对象,并以36例健康人为对照组,分别于治疗前和治疗后用流式细胞仪(FCM)测定血小板活化因子CD62p和CD63,用酶联免疫法测定血浆血小板第四因子(PF4)水平.结果 未经治疗的抑郁症患者血小板活化因子CD62p和血浆血小板第四因子(PF4)的表达水平明显高于对照组分别为(5.24±0.80)%,(2.60±0.64)%(P<0.01)和(7.68±0.79)%,(5.34±0.87)%,P<0.01];抗抑郁治疗后血小板活化因子CD62p和血小板第四因子(PF4)的表达较治疗前明显下降分别为(2.82±0.91)%,(5.24±0.80)%,P<0.01和(5.48±0.82)%,(7.68±0.79)%,P<0.01].结论 抑郁症患者存在血小板过度活化,西酞普兰抗抑郁治疗可能逆转抑郁症患者血小板的过度活化.

Clinical research of platelet activation function in depression patients

Objective To explore CD62p, CD63 expression on platelet and plasma platelet factor Ⅳ (PF4) level in depression and to seek the association between depression and platelet activation. Methods Thir-ty-six depressed patients and thirty-six healthy subjects were enrolled in this study. CD62p and CD63 expression on the surface of platelets were detected by flow cytometry at pre-treatment and post-treatment. Plasma PF4 level was detected by enzyme-linked immunosorbent assay. Results Before treatment expression of CD62p on the sur-face of platelets and plasma PF4 level were significantly increased in the depressed patients compared to healthy control(5.24±0.80)%,(2.60±0. 64)%, P<0.01 and(7.68±0.79)%,(5.34±0.87)%, P<0.01].Post- treatment expression of CD62p on the surface of platelets and plasma PF4 level in depressed patients de-creased compared to pre-treatment (2.82±0.91 ) %, ( 5.24±0.80 ) %, P<0.01 and ( 5.48±0.82) %, (7.68 ±0.79) %, P<0.01]. Conclusions This study demonstrate that the patients with depression display platelet su-per-activatian. Treatment with citalopram maybe reverse the increased platelet activation.