| 镁预处理对兔全脑缺血神经保护作用的实验研究 |
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| 引用本文： | 欧册华,张毅,李惠芳.镁预处理对兔全脑缺血神经保护作用的实验研究[J].四川动物,2009,28(3). |
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| 作者姓名： | 欧册华 张毅 李惠芳 |
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| 作者单位： | 1. 泸州医学院附属医院麻醉科,四川泸州,646000
2. 昆明医学院第一附属医院麻醉科 |
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| 摘 要： | 目的探讨硫酸镁预处理对兔全脑缺血神经保护作用及其机制.方法 45只兔随机分为3组:对照组(n=15)、缺血组(n=15)和镁预处理组(n=15).阻断血管,诱导全脑缺血,缺血时间为 6 min.测定缺血再灌注30 min 兔海马谷氨酸、天冬氨酸、γ-氨基丁酸和甘氨酸含量.检测缺血再灌注3 d 海马CA1区神经元密度和凋亡神经元密度.结果 (1)镁预处理组海马天冬氨酸和甘氨酸显著低于缺血组(P<0.01),而γ-氨基丁酸含量显著高于缺血组(P<0.05);(2)镁预处理组正常神经元密度显著高于缺血组 (P<0.01),缺血神经元密度显著低于缺血组(P<0.01);(3)镁预处理组凋亡神经元密度显著低于缺血组(P<0.01).结论 (1)硫酸镁预处理对兔全脑缺血有神经保护作用;(2)该保护作用的机制可能有:1)抑制兔全脑缺血再灌注30 min 海马天冬氨酸和甘氨酸的过度释放以及抑制γ-氨基丁酸的耗竭;2)抑制兔全脑缺血再灌注3 d 海马CA1区神经元凋亡.
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| 关 键 词： | 镁离子 全脑缺血 神经保护 预处理 |
Experimental Research of Neuroprotective Effect of Magnesium Sulfate Preconditioning on Global Ischemia in Rabbits |
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| OU Ce-hua,ZHANG Yi,LI Hui-fang.Experimental Research of Neuroprotective Effect of Magnesium Sulfate Preconditioning on Global Ischemia in Rabbits[J].Sichuan Journal of Zoology,2009,28(3). |
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| Authors: | OU Ce-hua ZHANG Yi LI Hui-fang |
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| Affiliation: | 1.Department of Anaesthesia;Affiliated Hospital of Luzhou Medical College;Luzhou;Sichuan Province 646000;China;2.Department of Anaesthesia;1st Affiliated Hospital of Kunming Medical College |
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| Abstract: | Objective To explore the neuroprotective effect of magnesium sulfate preconditioning on global ischemia in rabbits.Methods 45 rabbits were divided randomly into three groups: control group(n=15),ischemic group(n=15) and magnesium preconditioning group(n=15).Global ischemia was produced by occlusion of four vessels for 6 min.Glutamate(Glu),aspartic acid(ASP),gamma-aminobutyric acid(GABA),and glycine(Gly) levels in the hippocampus were measured 30 min after reperfusion.The densities of neurons and apoptosis n... |
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| Keywords: | magnesium ion global ischemia neuroprotection preconditioning |
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