| 上海地区汉族人单胺氧化酶基因微卫星DNA多态性研究 |
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| 引用本文： | 江三多. 上海地区汉族人单胺氧化酶基因微卫星DNA多态性研究[J]. 复旦学报(自然科学版), 1998, 37(4): 395-400 |
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| 作者姓名： | 江三多 |
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| 作者单位： | 上海精神卫生研究所!复旦大学(江三多，任大明，林嗣萃，钱伊萍)，上海医科大学(江开达，汤国梅)，上海精神卫生研究所(汪栋祥) |
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| 基金项目： | 上海市老年精神医学领先学科资助 |
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| 摘 要： | 应用扩增片段长度多态性技术，分析单胺氧化酶基因的ＭＡＯＡ（ＣＡ）。力ＭＡＯＢＩ（ＧＴ）ｎ２个基因座的微卫星ＤＮＡ多态性。在２４６名（男性１２２人，女性１２４人）无血缘关系上海地区汉族人中检出ＭＡＯＡ（ＣＡ）ｎ基因座８－种等位基因（１１０－１２４ｂｐ）和１９种基因型。
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| 关 键 词： | 单胺氧化酶 微卫星DNA 汉族人 上海 遗传多态性 |
A Study on the Microsatellite DNA Polymorphisms of Monoamine Oxidases Gene in Han Population of Shanghai Area |
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| Jiang Sanduo, Ren Daming, Lin Sicui, Qian Yiping, Jiang Kaida,Tang Guomei. A Study on the Microsatellite DNA Polymorphisms of Monoamine Oxidases Gene in Han Population of Shanghai Area[J]. Journal of Fudan University(Natural Science), 1998, 37(4): 395-400 |
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| Authors: | Jiang Sanduo Ren Daming Lin Sicui Qian Yiping Jiang Kaida Tang Guomei |
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| Abstract: | The microsatellit DNA polymorphism analyses of MAO A (CA)n and MAO B(GT)n locus in monoamine oxidase (MAO) gene were carried out by amplified fragment length polymorphism (Amp-FLP) techniques. Among 246 unrelated Chinese individuals (122 meles and 124 females), 8 alleies (size: 110~124bp) and 19 genotypes (in females) of MAOA (CA)n locus were observed. The heterozygosity was 0. 706 6, and the polymorphism information content (PIC) was 0. 704 7. In a sample of 238 unrelated Chinese individuals (119 males and 119 females), 12 alleles (size: 170~194bp) and 26 genotypes (in females) of MAOB(GT)n locus were observed. Its heterozygosity and PIC were 0. 772 7 and 0. 770 5, respectively.The Chi-square tests statistically supported that these genotyping distribution of these two loci were consistent with Hardy-Weinberg equilibrium. The family study demonstrated that MAOA(CA)n and MAOB(GT)n loci were X-linked inheritance. These genetic markers are of great significance of medical genetics and population genetics. |
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| Keywords: | monoamine oxidases gene microsatellite DNA polymorphism Shanghai Han population |
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