| 从受体水平分析β-内啡肽对淋巴细胞转化的调节作用 |
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| 引用本文： | 沈奕,张玲妹,姜建伟,吴根诚,曹小定,何球藻.从受体水平分析β-内啡肽对淋巴细胞转化的调节作用[J].现代免疫学,1992(6). |
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| 作者姓名： | 沈奕 张玲妹 姜建伟 吴根诚 曹小定 何球藻 |
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| 作者单位： | 上海医科大学神经生物学教研室，上海医科大学神经生物学教研室，上海医科大学神经生物学教研室，上海医科大学神经生物学教研室，上海医科大学神经生物学教研室，上海医科大学免疫学教研室 上海 200032，上海 200032，上海 200032，上海 200032，上海 200032 |
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| 摘 要： | 本文采用~(125)I-β-内啡肽放射受体结合分析法,证实活化的小鼠脾淋巴细胞上有与β-内啡肽特异结合的阿片受体。并观察到~(125)I-β-内啡肽与活化的小鼠脾淋巴细胞的特异结合可被非标记β-内啡肽或纳洛酮取代。但用同样方法,未发现β-内啡肽可与未经刀豆蛋白A(ConA)活化的小鼠脾淋巴细胞特异结合。上述结果提示β-内啡肽通过相应受体调节小鼠脾淋巴细胞的增生反应。
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MODULATION OF MOUSE SPLENIC LYMPHOCYTE PROLIFERATiON BY β-ENDORPHIN VIA OPIATE RECEPTOR |
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| Abstract: | Receptor for βb-endorphin expressed on activated mouse spleen cells was detected byusing the method of radio-receptor binding assay. Specific binding of β-endorphin to the receptor was found only on activated mouse splenic lymphocytes,but not on the resting, nonstimulated lymphocytes. This binding of β-endorphin could be blocked by unlabelled β-endorphin or naIoxone. These results suggested that the synergetic effect of β-endorphin on lymphocytes proliferation be mediated through the receptor of β-en dorphin. |
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