Synthesis of 4-(2,4-dioxo-5-pyrimidyl)-1,4-dihydropyridine derivatives |
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Authors: | Jungjin Suh Youhwa Hong Myn Bae |
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Affiliation: | 1. Yuhan Research Center, 433-810, Kunpo-Shi, Korea
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Abstract: | Hantzsch synthesis of 5-formyluracil (1), methyl acetoacetate (2) and methyl 3-aminocrotonate (3) gave 2,6-dimethyl-4-(2,4-dioxo-5-pyrimidyl)-1, 4-dihydropyridine-3, 5-dicarboxylic acid dimethylester (4a) in 54.6% yield. As the same procedure, 1,3-dimethyl-5-formyl-uracil (6) gave 2,6-dimethyl-4-(1,3-dimethyl-2,4-dioxo-5-pyrimidyl)-1, 4-dihydropyridine-3,5-dicarboxylic acid dimethyl ester (7a) in 52.2% yield.4a was methylated to afford7a also in 52% yield. |
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Keywords: | 1 4-Dihydropyridines nifedipine Hantzsch synthesis 4-(2 4-dioxo-5-pyrimidyl)-1 4-dihydropyridine |
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