Summary report on the ISOBM TD-6 workshop: analysis of 20 monoclonal antibodies against Sialyl Lewisa and related antigens. Montreux, Switzerland, September 19-24, 1997 |
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| Authors: | PD Rye NV Bovin EV Vlasova AA Molodyk A Baryshnikov FT Kreutz WI Garinther BC Schultes AA Noujaim R Madiyalakan J Magnani O Nilsson K Nilsson K Nustad L Norum H Bell Y Cao MR Suresh DL Very JV Freeman KK Yeung J Hilgers |
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| Affiliation: | Central Laboratory, Norwegian Radium Hospital, Montebello, Oslo, Norway. |
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| Abstract: | The ISOBM TD-6 Workshop is the first international workshop on monoclonal antibodies against the Sialyl Lewisa (SLea) antigen. Eight research groups participated in a blind study to characterize the epitope binding, relative affinity and performance in immunoradiometric assays, of a panel of 20 monoclonal antibodies. The antibodies were tested against a diverse panel of neoglycoconjugates, purified antigens and human serum pools from gastrointestinal malignancies. Epitope specificities were determined for the majority of antibodies in the panel. Cross-reactivity with related saccharide structures was noted in several antibodies. Overall, the results of the TD-6 Workshop show further development of SLea immunoassays may yield yet more specific assays for the detection and management of gastrointestinal and other malignancies. |
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