万古霉素等十种抗生素对耐苯唑西林葡萄球菌的体外活性比较

为了比较万古霉素等１０种抗生素对１９９５年分离的９５株耐苯唑西林的金黄色葡萄球菌和７２株凝固酶阴性葡萄球菌的体外活性，用ＮＣＣＬＳ颁布的琼脂稀释法测ＭＩＣ。结果受检的１０种抗生素中万古霉素的活性最好，其ＭＩＣ５０及ＭＩＣ９０分别为１ｍｇ／Ｌ及２ｍｇ／Ｌ，平均值为１２４ｍｇ／Ｌ；耐药率为０％。其次为壁霉素，其ＭＩＣ５０及ＭＩＣ９０分别为２ｍｇ／Ｌ及８ｍｇ／Ｌ，平均值为２５１ｍｇ／Ｌ；耐药率为２％。利福平ＭＩＣ５０及ＭＩＣ９０分别为０１２５ｍｇ／Ｌ及３２ｍｇ／Ｌ，平均值为０２２ｍｇ／Ｌ；耐药率为１４％。其它依ＭＩＣ９０的大小排序，为氧氟沙星，甲氧苄啶，红霉素，庆大霉素，磷霉素，磺胺甲恶唑等。用柱状图显示了前三种药的ＭＩＣ值的分离，万古霉素具有良好的分散性，全部落在敏感区，且为单峰。结果表明万古霉素对ＭＲＳＡ和ＭＲＳＣｏＮ有良好的抗菌活性。

Activity comparison of vancomycin and other 9 antibiotics to oxacillin resistant staphylococcus

The in vitro activity of vancomycin teicoplanin,phosphonomycin,rifampin,ofloxacin,erythromycin,gentamicin,trimethoprim and sulfamethoxazol to 95 strains of MRSA and 72 of MRSCoN isolated in 1995 were tested.Data showed that vancomycin (including vancomycin CP and nor vancomycin) was the most active antibiotic (the MIC50,MIC90,2mg/L and mean value was 1mg/L,2mg/L and 1. 24mg/L respectively),resistant rate of MRSA was 0%.Next came the teicoplanin (2,8 and 2.5mg/L),to which the resistant rate was 2%.The MIC50,MIC90 and mean MIC of rifampin were 0.125mg/L,32mg/L and 0.22mg/L,respectively,resistant rate of rifampin was 14%.According to the values of MIC90,the other antibiotics can be ranked in order as follows:ofloxacin,trimethoprim,erythromycin, gentamicin,phosphonomycin,and sulfamethoxazol etc.The histograms of MIC value of the front three antibiotics showed the MIC distribution of vancomycin located in sensitive area with single peak at 1mg/L.The result indicated that vancomycin had strong antibacterial activity against MRSA and MRSCoN.