S100A4蛋白在结直肠癌中的表达

目的研究S100A4蛋白在结直肠癌组织中的表达及其临床意义。方法应用免疫组织化学S-P法检测87例结直肠癌组织及癌旁结直肠组织中S100A4蛋白,并分析S100A4表达与结直肠癌临床病理因素及术后5年生存率的关系。结果在癌旁结直肠组织腺上皮中S100A4蛋白不表达;在结直肠癌组织中S100A4蛋白的表达率为64.4%(56/87);与癌旁结直肠组织比较,差异有显著性(P<0.01);S100A4蛋白在结直肠癌中的表达与临床分期、淋巴结转移及5年生存率有关(P<0.05),与其它临床病理因素无关(P>0.05)。结论S100A4蛋白和结直肠癌的侵袭和转移及预后密切相关;S100A4蛋白可作为判定结直肠癌临床病理特征及判断预后的重要指标。

Expression of S100A4 in colorectal carcinoma

Objective To investigate the expression and significance of S100A4 protein in colorectal carcinoma.Methods S-P immunohistochemical method was used to detect the expression of S100A4 in 87cases with colorectal carcinoma and 87 cases with adjacent colorectal tissues,and the expression of S100A4 was analyzed with relation to clinicopathologic factors and post-operative five-year survival. Results There was no expression in glandular epithelium of adjacent colorectal tissues. The positive rate of S100A4 was 64.37%(56/87) in colorectal carcinoma.There were significant differences between colorectal carcinoma and normal group(P<0.01).The expression of S100A4 was positively correlated with clinical stages, lymph node metastasis and five-year survival (P<0.05), but not with other clinicopathologic factors (P>0.05). Conclusion S100A4 is closely related with colorectal cancer invasion,metastasis and prognosis ;S100A4 might be an important predictor for the clinicopathologic features and prognosis of colorectal carcinoma.