食管鳞癌中血管生成素-2的表达及其与微血管密度的关系

目的 研究血管生成素-2(Ang-2)在食管鳞癌血管生成及肿瘤生长中的作用.方法 应用免疫组织化学方法 检测80例食管鳞癌和25例正常食管组织石蜡标本Ang-2和CD34表达,并以CD34标记的微血管计算组织的微血管密度(MVD).结果 食管鳞癌组织中Ang-2阳性表达率(70.00%,56/80)高于正常食管组织(24.00%,6/25)(P<0.05),食管鳞癌组织中Ang-2表达与肿瘤组织学分级、浸润深度及淋巴结转移有关,与MVD呈正相关(r=0.603,P<0.05),Ⅲ期和Ⅳ期合并者Ang-2阳性表达率(85.71%,36/42)高于0～Ⅰ期和Ⅱ期合并者(52.63%,20/38)(P<0.05).结论 Ang-2与食管鳞癌的血管生成及其发展密切相关,可能通过促进食管鳞癌中的血管生成而促进其发展.

Expression of angiopoietin-2 and its relationship with microvessel density in sqnamous carcinoma of esophagus

Objective To examine the expression of angiopoietin-2(Ang-2) in squamous carcinoma of esophagus,and discuss the relationship between Ang-2 and microvessel density(MVD)and clinical pathological features of squamous carcinoma of esophagus.Method The expression of Ang-2 and CD34 in 80 squamous careinoma of esophagus and 25 normal esophagus were detected by immunohistochemistry SABC technique,and the MVD of tissues signed by CD34 was counted.Results The expression of Ang-2 in squamous carcinoma of esophagus was,higher than that in normal esophagus (P<0.05).The expression of Ang-2 in the stage O-I and II squamous carcinoma of esophagus was lower than that in stage Ⅲ and lV(P<0.05).The expression of Ang-2 in squamous carcinoma of esophagus was correlated with differentiation of esophageal carcinoma and lymph node metastasis and infiltrative deepness.There was a remarkable posidve correlation between the expression of Ang-2 and MVD in squamous carcinoma of esophagus (r=0.603,P<0.05). Conclusion The expression of Ang-2 may be elated to the development of squamous carcinoma of esopha- gus,and may promote the development of squamous carcinoma of esophagus by promoting angiogenesis in tumor.