上皮型钙黏蛋白在胰腺癌中的表达和作用

目的：研究上皮型钙黏蛋白（E-cadherin）在胰腺导管腺癌中的表达及临床意义。方法：收集我院2001年1月至2006年6月间手术切除的60例胰腺导管腺癌石蜡标本,制成组织芯片,应用EnVision免疫组化技术检测上皮型钙黏蛋白的表达,结合临床病理资料进行分析。结果：正常胰腺组织细胞膜上皮型钙黏蛋白染色强阳性,癌细胞膜染色降低或缺失,上皮型钙黏蛋白表达在正常组织和癌组织中有显著差异（P〈0.01）。37例（61.7%）胰腺癌上皮型钙黏蛋白表达降低,上皮型钙黏蛋白表达降低与肿瘤转移、组织分化程度、TNM分期和预后密切相关（P〈0.05）。结论：上皮型钙黏蛋白表达降低可能是评判胰腺癌恶性程度、转移和预后的较好指标。

E-cadherin expression in pancreatic cancer and its clinical significance

Objective To investigate the expression of E-cadherin in human pancreatic cancer tissues,and its cli-nical implication.Methods The expression of E-cadherin in 60 patients with pancreatic cancer admitted during the priod from January 2001 to June 2006,was determined by tissue microarray and EnVision immunohistochemical staining.Results The expression of E-cadherin in the memberane of normal pancreatic cells was higher than that in cancer cells.The rate of reduced E-cadherin expression in pancreatic cancer tissues was 61.7%(37/60).The reduced E-cadherin expression was closely related with cancerous tissue differentiation,lymph node status,TNM stage and poor prognosis(P<0.05).Conclusions E-cadherin might be a sensitive predictor to evaluate the metastasic potential and the outcome of pancreatic cancer patients.