红细胞沉降率在评估系统性红斑狼疮活动性中的应用价值

目的评价红细胞沉降率是否可用于评估系统性红斑狼疮患者的疾病活动性。方法选择2012年6~12月共77例系统性红斑狼疮患者纳入本研究,诊断符合美国风湿病协会要求,男14例,女63例,红细胞沉降率、补体3(C3)、补体4(C4)、抗dsDNA抗体等检测项目于就诊当天完成检测,按系统性红斑狼疮疾病活动度评分表(SLEDAI)评分标准将上述患者分为活动期组(n=44,SLEDAI4分)和缓解期组(n=33,SLEDAI=0~4分),比较两组上述指标差异有无统计学意义,计算各指标与SLEDAI评分的相关性。双侧以P0.05为差异有统计学意义。结果活动期红细胞沉降率21(10,37)]mm/h,明显高于缓解期的11(5,21)]mm/h,差异有统计学意义(Z=-2.787,P=0.005),在区分系统性红斑狼疮活动与否能力方面,红细胞沉降率与C3、C4及抗dsDNA抗体相比,差异并无统计学意义(P0.05)),Pearson相关性分析显示,红细胞沉降率与SLEDAI评分呈正相关(r=0.293,P=0.010)。结论红细胞沉降率可用于对系统性红斑狼疮患者进行疾病活动性评估。

Application value of erythrocyte sedimentation rate in evaluating the activity of systemic lupus erythematosus

Objective To evaluate whether erythrocyte sedimentation rate (ESR) could evaluate disease activity of patient with systemic lupus erythematosus (SLE) .Methods Totally 77 SLE patients From June 2012 to December 2012 were included in this study ,diagnosis of American Rheumatism Association requirements ,male 14 cases ,female 63 cases ,ESR ,complement (C3 ,C4) ,anti dsDNA antibody and other test items completed detection on the day of treatment ,and allocated patients into two subgroups accord‐ing to SLEDAI score ,active group (n=44 ,SLEDAI>4) and inactive group (n=33 ,SLEDAI=0-4) .The above indicators of two groups were compared ,the correlation between each index and the SLEDAI score was calculated .Results ESR was significantly in‐creased in active group than inactive group21(10 ,37)mm/h vs .11(5 ,21)mm/h ,Z= -2 .787 ,P=0 .005] .On the ability to distin‐guish whether the activity of SLE ,there was no significant difference in between ESR and C3 ,C4 ,anti dsDNA antibody(P>0 .05) . Pearson correlation analysis showed that ESR was positively correlated with SLEDAI score (r=0 .293 ,P=0 .010) .Conclusion ESR can be considered as an useful marker for assessment of disease activity in patient with SLE .