| 辣木多肽对D-半乳糖致衰老小鼠抗氧化功能的影响 |
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| 引用本文： | 庞棋期,钱波,王程强,曾榛,雷少玲,宋家乐. 辣木多肽对D-半乳糖致衰老小鼠抗氧化功能的影响[J]. 现代食品科技, 2019, 35(5): 23-29 |
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| 作者姓名： | 庞棋期 钱波 王程强 曾榛 雷少玲 宋家乐 |
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| 作者单位： | 桂林医学院公共卫生学院,广西桂林541100;釜山大学食品科学与营养学系,韩国釜山609735;桂林医学院公共卫生学院,广西桂林541100;广西高校预防医学重点实验室,广西桂林541100;广西肽王生物科技有限公司,广西南宁5 30000;桂林医学院公共卫生学院,广西桂林541100;广西高校预防医学重点实验室,广西桂林541100;CHA医科大学食品生命工学系及生物技术研究所,韩国抱川11160 |
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| 基金项目： | 广西壮族自治区南宁市科学研究与技术开发计划（20181187-3）；广西教育厅广西高等学校千名中青年骨干教师培育计划资助（桂教人[2018]18号）；桂林医学院引进人才科研启动基金项目(04010150001) |
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| 摘 要： | 探讨辣木多肽(MOPP)对D-半乳糖致衰老小鼠抗氧化能力的影响。小鼠腹腔注射D-半乳糖(120mg/kg)建立衰老模型。建模成功后,分设正常组,D-半乳糖衰老组,维生素C组,MOPP低剂量(10 mg/kg)和高剂量(100 mg/kg)组。连续给药6周后,依试剂盒说明分别测定血清总抗氧化力(T-AOC),脑、心脏和肝脏及血清中超氧化物歧化酶(superoxide dismutase,SOD),过氧化氢酶(catalase,CAT),谷胱甘肽过氧化酶(glutathioneperoxidase,GSH-Px)和丙二醛(malondiadehycle,MDA)水平。q RT-PCR法测定肝内Mn-SOD、Gu/Zn-SOD和CAT的m RNA表达。与衰老对照组相比,MOPP能分别有效提高衰老小鼠血清T-AOC能力(至13.73～17.98U/m L),及血清SOD(8.04～11.65 U/mg protein)、CAT(4.56～6.45 U/mg protein)和GSH-Px(7.28～10.65 U/mg protein)活性,并显著提升脑、心脏及肝组织中抗氧化物酶(SOD、CAT、GSH-Px)活力(p0.05)。同时,高浓度MOPP还能使血清、脑、心脏和肝组织中MDA水平显著降低43.6%,44.7%,31.4%和56.0%(p0.05)。此外,MOPP干预还能增强肝脏中SOD、CAT和GSH-Px的m RNA转录。本研究结果提示MOPP能明显提高D-半乳糖致老龄小鼠体内的抗氧化状态。
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| 关 键 词： | 辣木多肽 D-半乳糖 抗氧化 氧化应激 氨基酸 |
| 收稿时间： | 2019-01-21 |
Effect of Polypeptide from Moringa oleifera on Antioxidant Capability in D-galactose Induced Aging Mice |
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| PANG Qi-qi,QIAN Bo,WANG Cheng-qiang,ZENG Zhen,LEI Shao-ling and SONG Jia-le. Effect of Polypeptide from Moringa oleifera on Antioxidant Capability in D-galactose Induced Aging Mice[J]. Modern Food Science & Technology, 2019, 35(5): 23-29 |
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| Authors: | PANG Qi-qi QIAN Bo WANG Cheng-qiang ZENG Zhen LEI Shao-ling SONG Jia-le |
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| Affiliation: | (1.School of Public and Health, Guilin Medical University, Guilin 541100, China)(2.Department of Food Science and Nutrition, Pusan National University, Pusan 609-735, South Korea),(1.School of Public and Health, Guilin Medical University, Guilin 541100, China)(3.Guangxi Colleges and University Key Laboratory of Preventive Medicine, Guilin Medical University, Guilin 541100, China),(1.School of Public and Health, Guilin Medical University, Guilin 541100, China)(3.Guangxi Colleges and University Key Laboratory of Preventive Medicine, Guilin Medical University, Guilin 541100, China),(1.School of Public and Health, Guilin Medical University, Guilin 541100, China)(3.Guangxi Colleges and University Key Laboratory of Preventive Medicine, Guilin Medical University, Guilin 541100, China),(4.Guangxi Taiwang biotechnology Co. Ltd., Nanning 530000, China) and (1.School of Public and Health, Guilin Medical University, Guilin 541100, China)(3.Guangxi Colleges and University Key Laboratory of Preventive Medicine, Guilin Medical University, Guilin 541100, China)(5.Department of Food Science and Biotechnology, and Institute of Biotechnology, CHA Medical University, Pocheon 11160, South Korea) |
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| Abstract: | |
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| Keywords: | Moringa oleifera polypeptide D-galactose anti-oxidation oxidative stress amino acid |
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