Palladium-catalyzed regioselective arylation of imidazo[1,2-a]pyrimidine |
| |
Authors: | Li Wenjie Nelson Dorian P Jensen Mark S Hoerrner R Scott Javadi Gary J Cai Dongwei Larsen Robert D |
| |
Affiliation: | Process Research Department, Merck Research Laboratories, P.O. Box 2000, Rahway, NJ 07065, USA. wenjie_li@merck.com |
| |
Abstract: | Imidazo1,2-a]pyrimidine can be arylated at the 3-position with aryl bromides in the presence of base and a catalytic amount of palladium. This provides an efficient one-step synthesis of 3-arylimidazo1,2-a]pyrimidines from the unsubstituted heterocycle. reaction: see text] |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|