鳞翅目昆虫抗病毒免疫反应的研究进展

鳞翅目昆虫种类繁多,对农业生产和人类生活产生重大影响,宿主昆虫与病毒相互关系的研究对于利用病毒杀虫剂进行害虫治理和益虫病毒性疾病的预防具有重要意义.因此,鳞翅目昆虫与病毒的互作研究显得尤为重要,宿主昆虫的免疫系统在抗病毒感染过程中发挥着关键作用,对病毒产生不同程度的免疫反应.本文综述了昆虫围食膜和中肠对病毒入侵的防御作用,病毒进入体腔后昆虫所产生的细胞免疫和体液免疫反应,以及RNAi、细胞的自噬与凋亡、Toll、Imd、JAK-STAT和STING信号通路等相关的抗病毒免疫途径,并对昆虫抗病毒免疫研究的制约因素和未来鳞翅目昆虫抗病毒免疫的研究重点进行了讨论,以期为害虫的生物防治和益虫疾病的防控提供理论依据.

Advance research on antiviral immunity response in lepidopteran insects

Lepidopteran insects are diverse and have a major impact on agricultural production and human life, the interrelationship between host insects and viruses is important for the use of viral insecticides for pest control and prevention of viral diseases of beneficial insects. Therefore, the research on the interaction between lepidopteran insects and viruses is particularly important. Insect innate immunity plays a key role in the process of antiviral infection, which produces different degrees of immune responses to viruses. This paper reviewed the defensive roles of insect peritrophic matrix and midgut against virus invasion, the cellular and humoral immune responsed generated by insects after virus entry into the haemocoele, and the antiviral immune pathways related to RNAi, autophagy and apoptosis, Toll, Imd, JAK-STAT and STING signaling pathways. We also discussed the constraints on the study of antiviral immunity in insects and future research priorities for antiviral immunity in lepidopteran insects, which would provide a theoretical basis for biological control of pests and prevention of beneficial insect diseases.