用单克隆抗体对ITP自身抗血小板抗体及其相关抗原的初步研究 |
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引用本文: | 胡昌军,王振义,徐也鲁,沈志祥,彭淼,蔡敬仁,陈淑容,沈倍奋,赵薇薇,白炎.用单克隆抗体对ITP自身抗血小板抗体及其相关抗原的初步研究[J].现代免疫学,1987(1). |
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作者姓名: | 胡昌军 王振义 徐也鲁 沈志祥 彭淼 蔡敬仁 陈淑容 沈倍奋 赵薇薇 白炎 |
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作者单位: | 上海第二医科大学
(胡昌军,王振义,徐也鲁,沈志祥,彭淼,蔡敬仁,陈淑容),军事医学科学院基础医学研究所
(沈倍奋,赵薇薇),军事医学科学院基础医学研究所(白炎) |
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摘 要: | 本文应用三种抗血小板膜糖蛋白单克隆抗体,按ELISA 间接法、ELISA双抗体夹心法、ELISA竞争法,对ITP患者自身抗血小板抗体及其相关抗原进行了初步研究。实验结果表明,抗血小板抗体的相关抗原呈多态性,包括:GPⅠb、GPⅡb及/或 GPⅢa,以 GPⅡb及/或 GPⅢa占多数,还可能包括血小板膜蛋白以外的其它抗原成分。这提示,ITP可能是一组复杂的、不均一的自身免疫性疾病。
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A PRELIMINARY STUDY ON ANTIPLATELET AUTOANTIBODIES AND THEIR RELATED ANTIGENS WITH MONOCLONAL ANTIBODIES IN ITP |
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Abstract: | We studied on antiplatelet autoantibodies and their related antigens in patients with ITP, by using three McAb against platelet glycoproteins, (anti-GPIb, IIb, IIIa),according to ELISA indirect method, ELISA sandwich method and ELISA competitive method. The results of the study indicated that the related antigens were nonhomogenous, including GPIb, GPIIb and/or GPIIIa and other components of platelet membrane .We suggested that ITP might be a complex and unviniform autoimmune disease. |
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