| 99mTc-奥曲肽SPECT/CT评价甲状腺相关性眼病活动期 |
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| 引用本文： | 戴皓洁,王雪,王峰,王颖.99mTc-奥曲肽SPECT/CT评价甲状腺相关性眼病活动期[J].中国医学影像技术,2011,27(3):505-509. |
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| 作者姓名： | 戴皓洁 王雪 王峰 王颖 |
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| 作者单位： | 1. 首都医科大学附属北京同仁医院核医学科,北京,100730
2. 首都医科大学附属北京同仁医院内分泌科,北京,100730 |
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| 摘 要： | 目的 探讨99mTc-奥曲肽眼眶显像对甲状腺相关性眼病(TAO)炎症活动度的评价效果。方法 对41例TAO患者(82只眼)行99mTc-奥曲肽眼眶SPECT/CT融合显像,并以10例无眼部疾病的肺癌患者(20只眼)作为对照。以临床活动性评分(CAS)作为标准,计算出其眼眶99mTc-奥曲肽摄取比值(UR)。结果 按阅片结果将82只眼分为阳性组(n=44)和阴性组(n=38),阳性组平均CAS为3.60±0.99,阴性组平均CAS为0.97±1.19,阳性组平均CAS显著高于阴性组平均CAS(P＜0.05),阅片结果与CAS的一致性为中等程度;TAO患者平均UR为1.54±0.50。按CAS将82只眼分为活动期组(CAS≥3)和非活动期组(CAS<3),活动期组(n=42)平均UR为1.80±0.49,平均CAS为3.81±0.99,非活动期组(n=40)平均UR为1.23±0.32,平均CAS为0.74±0.89,非活动期组显著低于活动期组(P＜0.05);UR与CAS呈中度相关(r=0.61,P＜0.05),ROC曲线下面积为0.803,区分活动期及非活动期TAO的UR阈值为1.38,其灵敏度为71.43％,特异度为80.00％。对照组平均UR为1.03±0.09,显著低于TAO组(P＜0.05)。结论 99mTc-奥曲肽眼眶SPECT/CT显像可以对TAO是否处于炎症活动期进行评估,使放射性核素显像的解剖定位更加精确,提高诊断效能。
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| 关 键 词： | 格雷夫斯眼病 锝 放射性核素显像 奥曲肽 |
| 收稿时间： | 7/1/2010 12:00:00 AM |
| 修稿时间： | 8/5/2010 12:00:00 AM |
Evaluation on activity of thyroid associated ophthalmopathy with 99mTc-octreotide orbital SPECT/CT |
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| LI Mei,DAI Hao-jie,WANG Xue and WANG Feng.Evaluation on activity of thyroid associated ophthalmopathy with 99mTc-octreotide orbital SPECT/CT[J].Chinese Journal of Medical Imaging Technology,2011,27(3):505-509. |
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| Authors: | LI Mei DAI Hao-jie WANG Xue and WANG Feng |
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| Affiliation: | Department of Nuclear Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China;Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China;Department of Nuclear Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China;Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China |
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| Abstract: | Objective To investigate the clinical feasibility of orbital 99mTc-octreotide SPECT/CT in evaluating clinical activity of thyroid associated ophthalmopathy(TAO).Methods Forty-one patients(82 eyes) with TAO underwent orbital 99mTc-octreotide SPECT/CT.Ten patients(20 eyes) of lung cancer without eye involvement(control group) underwent the same examination.Taking the clinical activity score(CAS) as standard,the uptake ratio(UR) of 99mTc-octreotide was calculated.Results All 82 eyes were divided into positive ... |
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| Keywords: | Graves ophthalmopathy Technetium Radionuclide imaging Octreotide |
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